Coronavirus Pandemic Update 94: Inhaled Steroids COVID-19 Treatment; New Pneumonia in Kazakhstan?

welcome to another

update

of Med Cram Cove in nineteen and can be seen in the world. Domenech countries seem to be the hot spots of the world. We may have reached a plateau in California, but the number of new daily deaths is slightly higher and of course those statistics. are delayed by several weeks in Texas, new cases continue to rise as our daily deaths it appears that in Florida new daily cases are also starting to flatten out a bit, however, it appears that daily deaths are beginning to increase significantly in Florida, we said we would be looking at Australia because of the winter season there and sure enough there has been an increase which is not clear if it is related to the season at the moment, there have been two deaths in July as a result, so far there is also one new concern with India.

As new cases continue to rise, daily deaths in India also continue to rise, but at a slower rate. I wanted to talk about

inhaled

cortico

steroids

for Cova 19. There is a lot of information out there now and we can only cover a fraction of what it is. This is happening and we may be able to have a good therapeutic intervention for Kovat 19:00, but until we have a randomized controlled trial showing that whether it works or not is simply speculation, many of you have been wondering yes or no. Ivermectin works or

inhaled

cortico

steroids

. What about nitric oxide? I've looked into these things and I have to admit that there is a lot of good data that is promising, but let's not forget the quality of evidence that we have to say that things really work well. be at least at the randomized controlled trial level and from there things move on to systematic reviews a lot of the data that we're seeing now with inhaled corticosteroids ivermectin nitric oxide things of that nature even some of the things that I've talked about about inclusion of acetal cysteine, here in cohorts, in case-controlled studies, case series, even in vitro studies, are even lower, so for us to be able to say whether something really works or not, we really need a trial randomized controlled or better, we currently have those trials in things, for example, severe REM and dexamethasone and that's why when we have one of these interventions that has that type of evidence and background, we will cover it here on make Ram because that's really important, but not This means that we are not going to cover some of the other things that may be promising and I think inhaled corticosteroids are one of those things.

Here is an article that is not a peer review, but was published a couple of weeks ago with the title Inhaled Corticosteroids. quick review of the evidence for the

treatment

or prevention of Cova 19:00 and of course we will put a link to this article in the description below and what this review does is look at the best evidence at the moment for using inhaled corticosteroids at kovat 19:00 discusses both the in vitro research as well as some of the case-control trials and case presentations of patients who were taking inhaled steroids and the conclusions they reached, they found that the in vitro studies showed that syphilis essen It had real antiviral properties, it also had lower immunosuppressive effects, however interestingly budesonide had no reduction in viral replication and there was no reduction in inflammatory cytokine release with budesonide.

They also don't see here that more research is needed, which, of course. It's true now, of course, remember that asthmatics who take corticosteroids all the time, in fact, according to this study that was published in respiratory care about five years ago, they found that inhaled corticosteroids were used between 22 and 63 percent. percent of patients with asthma and that's interesting when you look at this article that was published in MedPage Today here on May 5, 2020, even though from the beginning asthmatics were considered to be at higher risk for severe kovin outcomes 19, what they are finding here is that it may be the opposite, for example, in Wuhan, China, at the beginning of the

pandemic

they found that five percent of patients in China had asthma, but it was only seen in 1% of patients hospitalized for kovat 19.

Similarly, in New York, during the outbreak, their asthma was not even high. in the top 10 of the main morbidities found, despite the fact that almost 10% of the population of New York had asthma, one of the possible reasons could be because there are two receptors, which is the SARS Co v2 receptor, in fact , according to a new study in the Journal of Allergy. and clinical immunology demonstrated that respiratory allergy and controlled allergen exposure are associated with significant reductions in ace 2 expression and that ace 2 expression was lower in individuals with high levels of allergic sensitization and asthma, but again, It could be this connection with inhaled corticosteroids that led to a commentary published in The Lancet on Respiratory Medicine suggesting that asthma

treatment

s such as corticosteroids may play a role because up to 75% of asthma patients in China use in health corticosteroids that suppress corona virus replication and cytokine production in cultured cells and this is the Lancet Article that we will post a link to in the description below, so remember that we will need to do those randomized control trials before That we can recommend someone on a regular basis to take this type of inhaler if they are diagnosed with Fat Co 19 because remember that although the steroid inhaler can be used on its own for a week or two at most, if you are thinking about taking it as a preventative, remember that there are side effects that corticosteroids do not help and do not help.

They are not benign cataracts, osteoporosis,

pneumonia

, oral thrush, which is a fungal infection, are just some of the problems associated with long-term use of inhaled corticosteroids, so let's see how the data turns out on that. I am sure that we will receive information fairly. soon there will also be a study that one of our viewers passed on to us in terms of taking an active like cysteine. This is an article from the University of Virginia Health System that was published in 2007 titled "A Kind of Antioch May Not Be So Safe." as was once thought and basically this article talked about how mice were given eel cysteine ​​and it was discovered that in high doses they acquired pulmonary arterial hypertension.

That study was done on rats and this one was also published. This was only published two years ago. ago and what they found here was that NAC or an active eel cysteine ​​actually prevented the acquisition of pulmonary arterial hypertension in rats, so I'm not clear exactly what to make of NAC or an acetal cysteine ​​and the possibility that it causes pulmonary arterial hypertension. in humans, since both studies were done in rats, I think we all need to realize that any supplement we take can have side effects, but we have to weigh the risks and benefits of those studies: a study of an acidic cysteine ​​at 600 milligrams twice a day for six months was this study conducted by dr. of flora that was published in the European Respiratory Journal in 1997 and here they showed that the severity of influenza was greatly reduced even though the infection rate was not when we look at the article in terms of the adverse effects that you can see here what they were.

They are very, very minimal and you can see the ones listed here, so we will continue to look at these interventions as more and more studies come out and especially as we start to see more randomized control trials. I wanted to talk to you a little about some disconcerting news. Coming out of Kazakhstan and China, several news sites are picking up this information and it is basically information from the Chinese embassy warning its citizens about a

pneumonia

outbreak in Kazakhstan. They believe that it is a different entity from kovat 19 and that there are This year there are already a greater number of deaths from this type of pneumonia than last year, they do not say if it is a bacteria or a virus.

Apparently, Kazakhstan has officially recorded more than 50,000 Kovic cases, including two hundred and sixty-four deaths, and what they say is that pneumonia in Kazakhstan has killed one thousand seven hundred and seventy-two people in the first half of the year and six hundred and twenty-eight deaths in June alone, including Chinese nationals, the embassy said and according to Kazakhstan's state news agency. The number of pneumonia cases increased 2.2 times in June compared to the same period in 2019, so of course this is a fluid situation and we will be keeping an eye on this whether it is a different entity or No. an unacknowledged version of Cove at 19 is unclear.

We certainly don't have enough data at this time to independently verify whether this is new or more deadly than Cove at 19. The Kazakh government has responded to the Chinese report that this pneumonia is more deadly. that the

coronavirus

and we can see here that the Ministry of Health of Kazakhstan E called the Chinese media reports based on the embassy statement as fake news and further said that the information published by some Chinese media about a new type of pneumonia in Kazakhstan is wrong, the ministry said okay, see you in a next

update

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