Coronavirus Update 59: Dr. Roger Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)

line in Australia and it's interesting to note because Australia is entering the winter period here very soon, so it will be interesting to see whether or not there is a recurrence, as many people have said possible, of this sars curve 2 virus generating a comeback in the winter so we've been doing a lot of

update

s and been working on it for a couple of months here at Covet 19 and I thought I'd do a review and something quick to make it practical. and then the question is what am I doing for myself and why and what am I doing for my patients and why and as some of you know, I'm an internist and a critical care and pulmonary specialist, I'm also a sleep specialist and I've been seeing patients. with Covet 19 for at least a month.

I haven't had a fever, I haven't had a cough, and I've had a lot of questions about what we should do, so I thought. I would go over what my

regimen

is and why I do it and go from there and I think in the next video we'll talk about what I'm doing for my patients and why I'm doing it. Well, let's talk about

vitamin

C. Just keep in mind that any talk you give about

vitamin

C will be sadly disappointing because there is a lot of good information about vitamin C, particularly in lung diseases like ard syndrome and septic shock, and we have spoken before on Medcram about vitamin C. and its use in septic shock well, there is a study here that shows that vitamin C can shorten the length of stay in the intensive care unit in general and this was a meta-analysis that was conducted in 2019.

There is also a very good summary on Healthline. That begs the question: can vitamin C protect you from greed 19? And of course, we don't have any evidence particularly for greed 19 on almost anything right now, but you look at the data and you actually have very good resources on vitamin C. and effects and what kind of research is out there depending on the end point that Whether you care about the end result they get, they say there is no evidence that oral vitamin C supplements help treat or prevent greed 19. Of course there is a lot of information showing that intravenous vitamin C can potentially help in septic shock which was Dr.

Merrick's group in eastern Virginia and there's also another study called Citrus Alle that shows that vitamin C can reduce mortality in patients with ard, I mean, it can because mortality was a secondary endpoint in that study and, by convention, generally do not allow claiming something that was a secondary endpoint. However, do I take vitamin C? Yes, if I can get it in stores I take a supplement, but also have a bowl of fresh fruit in the morning, which has a lot of vitamin C and is probably more bioavailable, but you can get a lot of vitamin C from supplemental forms.

I'll talk in another video about intravenous vitamin C in patients with greed 19. in the intensive care unit, that's an important topic, we've already covered it for septic shock, but we'll get to it again. What about vitamin D? Well, there was this paper that was published in 2017 about 11,000 subjects in a meta-analysis of those taking vitamin D supplements and they asked whether or not it could prevent acute respiratory tract infections and the answer was yes. Here is a list of all the studies where they did the meta-analysis and you can see most of these charts. were to the left of this solid blue line running down the middle here at 1, showing that overall it had a statistically significant p-value of .001, meaning there was definitely a benefit to taking vitamin D supplements, but There were a couple of interesting side points to What they found was that if you treated 33 people with vitamin D supplements, you could prevent an acute respiratory tract infection, something that seems very common in many people, but is actually not that bad.

In general pharmacological terms, treating someone with aspirin for a myocardial infarction. is about the same number, they also found that it was better to receive a

daily

or weekly dose of vitamin D rather than a bolus dose when sick and that those with vitamin D deficiency, which, let me tell you, is not uncommon, the number needed to treat was only four, which is a surprisingly low number needed to treat, which of course means that the effect is very powerful. There was another study published at Trinity College Dublin that looked at Irish people and whether vitamin D could help them or not, this is completely new data.

It was just published a few weeks ago and this is known as the tilda or the Irish Longitudinal Study of Aging. What they found in this study was that in some people vitamin D supplementation could reduce the incidence of respiratory infections by 50 percent, that's 5-0 now. Of course, Ireland has many cloudy days. I suddenly live in Southern California, but I can tell you that several patients are vitamin D deficient and it's simply because we're inside all the time that we don't get the benefit. being in the sun, so it doesn't really matter where you are in the world, if you're inside all the time you're not going to get enough sun exposure to get vitamin D, so do I take vitamin D supplements? actually take about 2,500 international units per day, which is approximately 62.5 micrograms per day.

You may be wondering what the right dosage is for you and it's complex so it depends on your age and other factors so my recommendation is to talk to your health. health care provider and may need to be tested and given supplements and retested for some of you. I also take kercetin and I must say that the reason I take kercetin is because of the first studies on hydroxychloroquine, now hydroxychloroquine, since we have talked about it before it has a series of mechanisms that could inhibit the replication of the sars cov2 virus in the cell. One of these mechanisms is that it changes the pH of the endosomes that are necessary for the virus to enter the cell and that can prevent the virus from entering the cell.

Another mechanism is through a

zinc

ionophore, hydroxychloroquine. It is a

zinc

ionophore and as such, when zinc enters the cell, it can deactivate the replicase enzyme that the sars curve ii virus needs to replicate well, as it turns out that

quercetin

is also a zinc ionophore, kercetin, It is found naturally in onions, capers and other food products. You can get it without a prescription. I take about 500 milligrams twice a day and as a side note, a Chinese and Canadian researcher is studying kerosene in China to see if it makes any difference from Covet 19. Another supplement I take is an acetyl cysteine ​​also known as Knack and this is another over the counter medication and why I do it so well is because of this article from 1997 called Attenuation of influenza. -similar to the symptoms and improvement in cellular immunity with long-term treatment and with acetylcysteine, basically what it showed was that when 600 milligrams of NAC were administered twice a day for six months, although it did not reduce the chances of contracting influenza virus, significantly attenuated the severity of influenza-like illness, especially in older and high-risk people, and the difference was striking: 79 of the people in the placebo group had influenza virus symptoms, While only 25 percent of the virus-infecting subjects under NAC treatment developed a symptomatic form of the virus and basically what acetyl cysteine ​​does is help the liver in terms of reducing glutathione, reducing is the opposite of oxidizing. , so it's essentially an antioxidant and it helps the liver in terms of getting rid of toxins, by the way, this is also The same medication that we give to patients who overdose on Tylenol again helps the liver, so I take 600 milligrams two times a day.

Well, I also take a zinc supplement and if you want to know more about why, we just talked about replicase. sars curve 2 enzyme, but you can also go back and look at Medcram

update

s numbers 32 and 34. So I only take about 50 milligrams of zinc during these time periods when I think I might be exposed to the virus. You need to be careful. take 50 milligrams of zinc per day because it is above the recommended

daily

dose of 40 milligrams and there is some concern that taking doses higher than 40 milligrams per day may decrease the amount of copper the body can absorb, so it is not something I would do on a regular basis.

Now the other thing that I try to do on a regular basis is sleep, which may seem crazy, but we actually have good data that sleep is really important and if you want to learn more about sleep, I encourage you to check out our sleep updates. Medcram. numbers 16 17 and 45 and the amount of sleep I like to get here is seven to eight hours a night. Now I'm going to tell you about my routine when I go to work because I see patients with greed 19 almost on a daily basis, but I will tell you that nurses and respiratory therapists are exposed to those patients much more than I am, so part of the reason Why I'm doing this is to make sure they are protected too. seeing any of the nurses or people I work with get sick with this virus so the first thing is to talk about going to work and of course I'm going to work on my car and the things you should have on your car number. one is you have to have hand sanitizer, you have to have a trash bag, you have to have disinfectant wipes, you also have to have a surgical mask right now, in California, we have to have a mask if we get out of the car and walk in public. area and that would mean going to a hospital, so when I get up and go to my car to go to work, I have two layers of clothing and it's usually underpants and then I put on my medical gown, so I get in my car. and I drive to work when I'm at work I usually put on an n95 mask and cover it with a surgical mask that n95 mask is mine for the rest of the day and some of the hospitals I work at will recycle that mask and give me a mask new n95 mask or a recycled n95 mask the next day but what that surgical mask allows me to do is protect that n95 mask which is more valuable and I can take off the surgical mask when I leave a patient room because the virus can be transmitted through the air and it can sit on my surgical mask and that way I don't have to worry about contaminating my n95 mask.

The other thing you want to do is make sure you follow your protocol, whatever it may be. in your job in terms of getting in and out it's almost a piece of cake putting on personal protective equipment what's really difficult is remembering what order to take it off in and making sure you don't contaminate yourself and the general rule of thumb generally speaking is, no matter what you do, you always end up with hand sanitizer, so generally speaking, what he was doing after you'd gone to see a patient and he walked into the anteroom or the room right before you left is you take off your shoe covers. and then disinfect your hands then take off the cap on your head and then disinfect your hands and then you will remove the n95 mask surgical mask and then disinfect your hands then you will remove your gown and then disinfect your hands or somewhere order up to that point before you finally go out with only the glasses that protect your eyes and the n95 masks, then wash your hands well with soap before touching your face, of course, and try not to touch your face at all, sometimes I would even use papers, as they are called, to make sure you have positive pressure around your face to make sure you don't breathe in the virus and these are especially helpful if you are doing procedures that could cause aerosolization of the virus, then when you end up at the end of the day, it's time to head home.

Some staff I know would sometimes take a shower and bring an extra change of clothes and shower there in the hospital. I decided not to do that, but when I got to my car I didn't want to contaminate it either and since I had another layer of clothing underneath, I would take off the first layer at work and then throw it in the trash. bag that I had on hand in the car, then I used hand sanitizer, I used wipes on my shoes because you know there has to be viruses on the floor, so I would wipe my shoes and put all my clothes in a trash bag.

I would put it in the trunk, I would hand sanitize it, I would hand sanitize the steering wheel and at that point I would drive home if you need to get gas, make sure you have a proper first layer of clothing so you can get in the car. gas station, then when you got home I would make sure to take off my shoes in the garage as well as almost anything else I could in the garage and depending on who you talk to, the nurses, the doctors, they will tell you if they are or not . You are either completely naked in the garage or you have underwear on.

Typically, those clothes would also go in the trash bag and those clothes would go straight into the washing machine and heat up, while I would go straight into the shower before going anywhere else. but it's not just any shower that I would take, it was five minutes of the hottest you could get and then a minute of very cold as much as possible.cold as you could and then three minutes as hot as you could and then one minute. as cold as you can and then three minutes as hot as you can and finally finish with one minute as cold as you can and in total that would be 14 minutes of showering, so you're probably wondering why should I do that?

Get it right, if I had gotten the virus it would have been here at work and when I get home we are within 12 hours because each shift is about 12 hours so if there is any time I want to have a good immune system specifically a good innate immune system that's the time you would have it what does this have to do with a good immune system? We've talked about this before, especially in medcram updates 46 and 47. One of the things we talked about in update 47 was this thing called a contrast shower where you do five minutes hot one minute cold three minutes hot one minute cold three minutes hot one minute cold and that's exactly what What I'm doing now is remembering that we don't have any randomized controlled trials with Covid19, we don't know the level of evidence that we normally feel comfortable with what works. with Covet 19 and many of the things I'm showing here.

I don't have absolute proof that it works, but a lot of the things we're doing here really don't have much risk. In an upcoming video I'll show you some of the things. what we're doing for the patients and what I'm doing for the patients and we'll look at that data and look at the evidence on that, but in the meantime I wanted to show you what I was at least doing to protect myself and also my family thank you for joining us.