If You Get COVID 19: Optimize Immune System (Vitamin D, Monoclonal Antibodies, NAC, Quercetin etc.)

found patients with

antibodies

against interferon and, again, those interferon levels were very low in these patients and only these patients were found in the severe category. In other words, there were never any patients with

antibodies

to interferon in the mild cases, whereas if we look at patients who did not have any mutations and did not have antibodies to interferon, here we see a large number of responses to interferon, and these patients They were milder. So because of all of this, it seems to me that any possible way that we can improve, particularly the innate

immune

response early in the course of this disease, there is a chance to limit the progression, because of what we're seeing in terms of the signature of COVID-19, which is the suppression of interferon.

Well, if you look at the data in terms of the innate

immune

system

, in terms of the response to interferon, and in terms of fever, it's been well studied that fever can, in fact, enhance the response to interferon, as indicated here a representative post here. in 2002, and what they did here was stimulate human monocytes using whole-body hyperthermia. These were 12 healthy volunteers, who were immersed in a hot water bath at 39.5 degrees Celsius to increase their body temperature, and what they discovered was that three hours after hyperthermia in vivo, the response of monocytes to the endotoxin was improved by an ex vivo experiment.

Lipopolysaccharide stimulation assay. Basically, what they are doing there is giving the body a stimulus to tell it that there is an infection and see what happens, and what they found was that there was an increased expression of the release of tumor necrosis factor alpha and they concluded The thermal effect of the Fever directly activates monocytes, increasing their ability to respond to a bacterial challenge. And this is part of the reason I was hesitant to treat a fever that did not exceed 103 degrees Fahrenheit early in the course of the illness, because it seems to me that the fever is enhancing that same part of the immune

system

. - the innate immune system - which is necessary to end the progression of COVID-19, but there were more studies.

In this, researchers from the University of Toronto took seven healthy volunteers and looked at the effect of cold water at the end of the warm-up and exercise. In other words, warm them up, give them exercise, and then put them in a cold bath to see what happens to the natural killer cells, lytic units, etc., and this is exactly what they found: They said this study suggests that, despite According to the popular belief that exposure to cold can precipitate a viral infection, the innate component of the immune system is not negatively affected by a brief period of exposure to cold.

In fact, it seems to be the opposite. The drop in core body temperature resulting from cold exposure caused a consistent and statistically significant mobilization of circulating cells, an increase in natural killer selectivity, and elevations in circulating IL-6 concentrations. But the real tour de force in terms of publications was this one titled "Hyperthermia in humans enhances interferon beta synthesis and alters peripheral lymphocyte population." Basically, mitogen stimulation is something that stimulates the cells of the immune system as if there was a foreign invader, and what it showed was that when they took interferon and measured the amount of interferon that was released from lymphocytes after mitogen stimulation at different temperatures body parts, there was a tenfold increase in the response to interferon at 39 degrees Celsius and, again, this is the same molecule that is missing, as we discovered earlier in the initial course of COVID-19, which led me to think, is it It is possible that Early in the course of COVID-19, if we did hyperthermia in some way, could it alter the course and progression of this disease?

And at first this sounded a little far-fetched. Is it something so simple that could have such a big benefit? Well, first of all, we don't know if it has a great benefit, but if we look back in history, things like this have been done before and I looked at the example of Dr. Julius Wagner-Jauregg, who was an Austrian psychiatrist and he noticed that his Neurosyphilis patients got better when they had a fever, so he went ahead and infected them with malaria on purpose and essentially cured them of their neurosyphilis simply by the malaria fever, and then cured them of their malaria using the techniques known at the time for it. .

Dr. Wagner-Jauregg received the Nobel Prize in Medicine in 1927, and as you can see here based on this article published in 2013, simply immersing the individual in a hot bath or placing them in a thermal cabinet was one of the means by which This was done, and I suspect that many of these techniques were forgotten because the following year after Dr. Wagner-Jauregg won his Nobel Prize, in 1928, we discovered penicillin and opened a completely new therapeutic door. and again, I don't have data from randomized, placebo-controlled trials showing that hydrotherapy is effective in treating COVID-19, but there seems to be biological plausibility that it could work, which is why I'm interested in seeing the data of randomized controlled trials being conducted. and studies are being done to see if this really works or not.

What are the risks of hydrotherapy? Well, you have to use hot water and therefore there is a chance of burning yourself. There is also the possibility of heating someone's body to the point that they could have arrhythmias, although that seems to be quite rare. Other than that, the risks seem to be pretty minimal. You don't need to leave your house; no need to write any recipe; and you are not using resources that someone else should use. So I think the benefits outweigh the risks of hydrotherapy currently, and if anyone is interested in doing more research on this, I'll have links in the description below.

Kyle: Could people also use hot and cold showers or a hot tub or sauna if they have access to them to get the same effect? Dr. Seheult: Yes, absolutely. It's just a matter of raising the temperature. So, for example, the problem with some spas, at least in the United States, is that their maximum temperature is set at 104 degrees Fahrenheit. That may not be enough to raise core body temperature. You really want to be sweating; This is how you know you're reaching your core body temperature above where it should be and you don't want to do it for too long; around 20 to 30 minutes is probably enough.

In terms of showers, as you'll notice when we talked about this in Update 59, taking a hot shower followed by a cold shower is what we call a "tonic" or something that keeps your immune system in sentinel mode. looking for things, if you really get the disease. I don't know if just doing contrast showers will be enough to really activate the immune system, so sauna would be great, spa would be great. If the temperature could be raised, water baths, hydrotherapy where they use hot towels to warm and then cover the patient. Generally speaking, what you want to do is warm your body comfortably, so make sure you have a cold towel on your head or neck, so the temperature doesn't get hot in your head, just in your body.

Do this for about 20 minutes and then do a very quick cool down at the end, and allow it to stimulate the part of the immune system that is suppressed in COVID-19. Kyle: If someone tests positive and is not sick enough to need to go to the hospital and return home, what are some strategies they can employ to prevent other people they live with from getting sick? Dr. Seheult: Yes, and this is the real problem because the spread occurs at home. A great analogy you can use if you are in a house is to think about someone who smokes in your house.

If they're smoking on the other side of the house, you may not be able to smell the smoke, but over a long period of time, that smoke will basically infiltrate the house and eventually you smell that smoke, and that's how it really is. with the spread of this virus. So you have to think about both modes of spread if you want to prevent both modes of spread, and the first mode of spread is with large droplets, and that's where masks come in. So these large droplets will contain the virus. , and if someone is talking to you, these droplets will fly a few meters, but on the other hand, you will see, as we talked about smoking, that you can be on different sides of the house wearing a mask, but eventually, the other way the virus spreads , which are small airborne particles that simply become suspended in the air.

The way to avoid this is to rotate the air, so by having a closed house with the windows and doors closed, you won't get the type of air exchange that you need, and thus reduce the amount of COVID transmission through the air, opening the window, ventilating the house, putting some hepa filters in your air filtration or even portable air filters too. Having all of these things going at the same time is a multi-pronged approach to preventing the spread. Now the other thing you should do is isolate the person who tests positive in one area of ​​the house.

They may open the windows in that area of ​​the house, have active air filtration, maybe they will have to wear warmer clothing to compensate for the window being open, but again, these are all things that can work together. I think opening the window and achieving air exchanges and ventilation is even more important than the time we spend cleaning surfaces. In reality, that's probably not how this virus spreads. Kyle: Okay, Dr. Seheult, long story short: If I had a positive COVID-19 test and I have no symptoms or mild symptoms, I would recommend potentially getting a pulse oximeter and checking to see if I'm okay. the category of patients who could benefit from prophylactic

monoclonal

antibodies, you know, antibodies before they get sick, a variety of immune boosting strategies, including

vitamin

D and some other supplements, hyperthermia, if I have the opportunity to do that, if it's with hot towels or a hot tub or a bath or hot and cold showers or a sauna if you have access to that: sleep, try to

optimize

my sleep, sleep at least seven hours a night and then certainly try to prevent spreading to other people, so I isolated myself at home as best I could, opened a window a few inches to ventilate, considered replacing the air filters in my heating and cooling system with a high efficiency filter, and I believe it is a MERV 13 or higher than you really want to capture those virus particles and finally, if one can afford it, a portable HEPA filter unit.

Anything else I'm missing? Dr. Seheult: No, I think that's actually the easiest part of the purpose of making this video, Kyle, is because I get a lot of people asking me, "Dr. Seheult, what do I do?" I have COVID-19 and I feel sick. It's been three or four days, what do I do?" And now what I'm going to do is just refer you to this video, because I think everything you just said there, Kyle, is everything I've been telling the people for the last two years, of months who have been calling me about "what do I do?" This is exactly what I think we should be doing and hopefully it will start to flatten the curve, in addition to everything else we know that is helpful, including wearing masks, social distancing outdoors, and all those other things we need to be aware of by doing.

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