Vit D research, definitive and significant

Well, war and welcome to today's talk, Wednesday, March 13. I'm going to share with you some pretty important vitamin D

research

data from Italy now and you can decide if you want to see it now. According to this

research

, vitamin D supplementation has a protective effect. effect against covid-19 case in randomized controlled trial studies but of course Co is just another viral infection so we would expect this to be effective against all viral infections that evade because it is optimizing the immune system against which we would expect it to be effective. all bacterial infections because they optimize the immune system, but Co is an interesting example and that's where the data is, so we'll stick with it.

Now the numbers here, the odds ratio is 0.43 and that means it has about a 60% protective effect. Therefore, people who have good levels of vitamin D are 60% less likely to get the infection compared to those with low levels of vitamin D. It is actually quite impressive and in the randomized control that Tri performed on factory workers health, the general reduction of risk in the population. supplemented with vitamin D was about 80%, so about 80% protection in healthcare workers and these are particularly relevant because they were well-conducted clinical trials, so this is pretty compelling data, so Why wouldn't you want to reduce your chances of getting it? an 80% viral bacterial infection, why wouldn't you?

It's pretty obvious, really moving against Covid-19 funding, in analytical studies, so it was randomized control studies in analytical studies, cool, it's an odd ratio of 0.592, so that's it. What a protective effect of just over 40%, still pretty good, but the data from the randomized control trial was of course the most likely to be accurate now against the incidence of Covid-19. Admissions to intensive care. Look, that odds ratio is 0.317 that's getting a 70% protective effect, so we have these protective effects against getting Covid. In the case of Covid, these people may still be getting it, of course, but they don't get tested and get it because they probably aren't getting it.

Symptomatic patients probably had very minor infections and they were not testing, um, those are the analytical studies and that is the reduced incidence in intensive care by almost 70%, so that's what it is, if you want to stay now with our meta-analysis, this It is the conclusion of our goal. The analysis suggests a definite and

significant

association between the protective role of vitamin D in Covid-19 incidents and ICU admissions, so this is actually a pretty compelling study from Italy. Now let's look at some of the details. This is the title of the study that was provided here. vitamin D supplementation of covid-19 infection risk a systematic review and meta-analysis is published in the peer review journal nutrients that is the article available in PDF, download it yourself or freely available which of course , is very generous. the magazine published on February 28, 2024 now the authors say that this vitamin D has crucial functions in bone homeostasis, well, we know that strong bones because its deficiency causes rickets, muscle function, oncogenesis, this is the formation of cancers, we now believe that good levels of vitamin D are protective.

From our conversations with Professor Angal Gish, there is probably an all-out against a wide range of cancers simply by optimizing vitamin D levels and this makes sense because by optimizing vitamin D levels you are optimizing the immune system and if you optimize the immune system, you optimize immune surveillance and that can detect cancers at an early stage and hopefully eradicate the vast majority of them or certainly a large number of them, so oncogenesis, immune response and metabolism are important now in the context of covid-19. Numerous researchers have tried to determine the role. of vitamin D in the immune response to the virus systematic reviews and meta-analyses in this case now they did it, the day they actually did this data, they collected this data was May 15, 2023, so obviously it takes a while to put together a paper complicated like this, but that was like the cutoff point for the data, so fair enough, it's pretty up-to-date data. um preventative vitamin D supplements found 16 good publications on those 1.26 million people.

I mean, this is just a lot of data. that has been included in this, what did I say, 1.26 million people, a large number of participants, a protective role in the incidence of covid-19, as we have said, um mortality, the article cannot really provide firm data on That's why we need more studies. About that, but admission to intensive care units surely calculated the odds ratio, evaluation of possible bias and evaluation of study quality will be carried out by independent researchers. Now, if you read the article, they give all the details of how this was done and It's a very comprehensive piece of work that is leading to some pretty conclusive conclusions, because, as they've said,

significant

conclusions and basically conclusive given that we know this now and I think which is fine, we can't say we know because we haven't had expensive randomized double blind control trials, firstly because no one wants to pay for them and secondly, of course, it will be unethical to artificially reduce vitamin levels D of people and then exposing them to infections because we have reason to believe that many of them would probably die.

So this is some good combined data that we have here and I'm clearly convinced of it, as you can see, in part because it's very consistent with all the other data that we've been looking at, in fact, quite a few of the articles here that we've seen previously in this channel and of course we have spoken to many of the people who have done the original research, now there is just additional information here that increases the veracity of this, really most of the effects of vitamin D are mediated by vdr receptors of vitamin D, so you know this, what's happening now?

You have vitamin D, it fits into a receptor, the combination of vitamin D and the receptor. You jog and you do something that triggers what we call the secondary messenger system and the activation of vitamin D, which very often is the activation of genes and of course a lot of those genes are in cells that are important like the cells in the brain. immune system, so it makes scientific sense, which is always reassuring, so the Vitamin D is mediated by vitamin D receptors, which promotes the expression of genes that contain specific DNA sequences in the uh, expressed in almost all nucleated cells, so the vitamin D receptor is found in virtually all nucleated cells and, of course, in basically all cells in the body. of red blood cells and certainly all white blood cells have these vitamin D receptors that are so important for immunity, so it makes sense because it's vital to have all this DNA, you know if you have all this kind of useful DNA there. that can promote immune response sponsors and optimize metabolism and do other things like that if you can't use it, um, if you don't have the vitamin D receptors that activate the vitamin D receptors with the vitamin D to activate all these genes, then No It helps a lot, it's a bit like having money in your wallet but you can't open it.

You know the potential is there as humans, we just have to optimize it for our health, so they're all around about three. % of the human genome is under the control of this activated form of vitamin D. It's pretty amazing. 3% of the human genome needs vitamin D to function properly, so in us we probably have about 21,000 active genes, so we can see that many of them, 3% of them need vitamin D for normal physiological activation Why don't the medical authorities understand it? It's really not too difficult to understand. It has been observed that vitamin D contributes to the synthesis of defensins.

These are small immune proteins and they are essential in enhancing phagocytic activity, so bacteria are GED for phagocytic F Fage means eating cytic cells eating cells that will eat viruses and bacteria, which of course is a good idea if you want to get rid of of them um and modulate the immune system response by regulating the inflammatory cascade so it's important that people with vitamin D are less likely to suffer from this runaway cytoinflammatory storm that of course kills so many people killed so many people in the pandemic and, uh, it kills a lot of people.

Still from sepsis, why wouldn't we want to mediate a pathological reaction to an infection? Because we don't have the vitamin D to buffer it. Now, the last image I have to show you here is the one that Professor Anderson just sent me. this from Italy caly dial this is the activated form of vitamin D, so when you take vitamin D in tablet form, like you normally buy it in the supermarket, it takes a week or two to activate it in this active form, so if you have a someone who is acutely ill and you give them vitamin D, they won't get an immediate benefit, but if you give them the activated form that is here, this is the calculation.

If they mark the already activated form that is already available in Italy, then there is a very good reason. believe that it has an immediate benefit because this quality works in a couple of hours. We got that information from Dr. Grimes just a week or two ago. It works in a couple of hours, while vitamin D taken orally takes a couple of weeks to work. So if someone is already supplemented with vitamin D and they get an infection, they are in the best position to fight that infection, but if someone gets an infection and their vitamin D is low, then they can supplement with this and it works very quickly in an couple of hours and that means it actually works much faster than antibiotics, so if someone has a viral infection, antibiotics won't work, but calid could probably help them.

If someone has a bacterial infection, they need antibiotics, but why not optimize their immune system? system also making sure they are topped up with calidi if their vitamin D levels are low, so in my opinion everyone who comes in with an acute infection should have their vitamin D levels monitored and if their vitamin D levels are lows, it should be considered to boost it with calid we really need studies on this but of course vitamin D and calid are not very expensive while the new Big Farmer drugs tend to be astronomically expensive. I'll leave your own conclusions from what I've said there for now. uh thanks for watching and it feels good that we've been vindicated because we thought this was the case at the beginning of 2020 and the research backs it up.

Vitamin D reduces the incidence of getting covid in the first place, it reduces the likelihood of going to intensive care. Be careful and if studies were done, I suspect we would find the same thing for a wide range of viruses and bacterial infections because we are optimizing the immune system in terms of vitamin D physiology, which is essential for the activation of 3,000 genes for the main one. Medical officers. I hope you watch this video and act on it in a few days or not, but you already saw it and thank you for watching.