Music Medicine: Sound At A Cellular Level | Dr. Lee Bartel | TEDxCollingwood

Many years ago I grew up on a honey farm in Western Canada, so every summer and fall I was in the honey house extracting honey from the comb, very sweet work and without fail, a couple drops of honey would fall into one The belts of what machines are and they began to make squeaks, squeaks, squeaks to drive me crazy and, with the same inevitableness, a cricket entered the honey house and made squeaks, squeaks, squeaks. What always surprised me was that it didn't take long before. what started out as some sort of random squeak would synchronize with the belt squeak why this would happen was a question that lingered in my head for many years until I discovered the Trainmen physics principle of how a rhythmically vibrating object will synchronize . with another and then I used that idea and started creating

music

to affect your brain waves,

music

like this.

Music that was enjoyable but had a very specific rhythmic structure that would allow me to help you go to sleep, help you relax, and even help you concentrate many years later. I started doing this I discovered that I could use a single tone like this 40 Hertz I remember this very low

sound

it's like the low E on the piano but with this I discovered that I could help people reduce their pain and even reduce the symptoms of Alzheimer's these three

sound

s Cricket, music and low frequency tone are potentially musical

medicine

. Each of these sounds has a rhythmic structure that allows it to impact the cells of your body.

In fact, my recent research has shown that stimulating cells with sounds like this can reduce the risk. and the impact of some common health problems, this is where you are supposed to say wait, what if? There are two parts to this that I need to break down so you can understand what I understand the first is how sound affects cells. in the body the sound that includes music but not all sounds as music but all music as sound is in essence vibration, molecular compressions in the air that reach your ear or your skin if you feel it as vibration as you would have done with a 40 Hertz, the ear has hair cells in the cochlea that translate this vibration into electrical signals for the auditory nerve to take to the brain, so when you hear a click like this, what happens is that compressions of air molecules reach your ear and your ear translates that into an electrical impulse and sends it to your brain, something like that, so it goes up the nerve and gets to the neuron, except it's not just one it's in, it's probably thousands or millions. of neurons that are responding directly to that. click just a little bit of information here when we have a click in our ear we call it a Hertz as a measurement by how many per second when it's five per second we call it five Hertz when it's 40 we call it 40 Hertz and brain waves are measured from the same way as hertz, so a sound of 40 per second or 40 hertz will be called gamma because it is in the category of gamma brain waves.

The other part of my claim is that brain waves are important for health issues, so let's look at that for a moment what we know about the brain is that, although there are millions of neurons, they do not fire randomly and unconnectedly, which What we know is that neurons that activate together connect with each other and that is why we have circuits within our brain, for example the motor circuit. The circuit is multiple parts of the brain that need to connect so that you can start a movement so that you can control that movement and stop it.

The memory circuit again connects multiple parts of the brain so that what you are experiencing now can really be. able to remember tomorrow as the perception of present experience is converted into short-term memory and long-term memory. What we know most about the brain is that the healthy circuits that work for you now require constant brain waves; In other words, if one part of the brain goes like this and the other part occasionally goes like this, they are not going to connect this circuit will not work and what we know is that the frequency at which neurons like to connect and respond most easily is around 40 Hertz, there seems to be a pattern that develops here when circuits don't work properly bad things happen, for example when the parts of the brain that are supposed to initiate and control movement don't connect, you may not be able to initiate a movement like in dyskinesia or not being able to initiate movement. it stops like a tremor so you may have Parkinson's when the parts that are supposed to give you long term memory don't connect you may have dementia or Alzheimer's so let me talk about a case of Alzheimer's that we treated, she had been diagnosed with Alzheimer's. 6 months before she came for our experimental 40 Hertz low frequency acoustic vibration treatment, we gave her a prescription of 30 minutes of 40 Hertz sound stimulation three times a week for four weeks and used this chair, the following chair of waves that had speakers built into it. on her six speakers so that that 40 Hertz low frequency sound you heard actually felt like a vibration.

At the end of the 12 weeks, we noticed that her test score had increased. She was giving us indications that she could remember her grandchildren's names more easily. she seemed to be more cognitively engaged and so the question is: what is it about forty hertz stimulation like vibrations that could make this happen? Why would this happen in the case of Alzheimer's? So one of the things we know about Alzheimer's is that as a person develops this, there seems to be fewer neurons that fire together at the forty Hertz

level

, so there's less power and forty Hertz, which means that The circuits are failing.

We also know, of course, that sound stimulation increases 40 Hertz firing and therefore we can increase the number of neurons that fire. at 40 Hertz and hopefully restore those circuits to the beginning of cricket, so let me tell you about a study that we did next, where we took 18 patients, this was just a short little study to see if we could have any effect and we distribute them in mild patients. to severe we used watching a DVD as a control and the prescription was 30 minutes of sound stimulation in this chair at 40 Hertz twice a week for just three weeks, so a total of three hours of stimulation and the results surprised us, which We saw it was not just in effect in each session, which is what we thought could happen, but this was accumulating two sessions over three weeks in the entire sample, we had a 13% increase in the test score, we got results from patients like the people who said in the third. week oh, I remember doing this before and generally more engagement with the world around them and in conversation, so very strong evidence that stimulation could improve.

Note that the DVD had a negative effect. They just got bored and worse from watching the DVD, so one of the questions that came up from that study is how long does this last? Can we have this effect for three weeks? Then what would happen if a person continued this for a while? So this is our first case after the 12 weeks which they were quite happy with. the results and they wanted to continue even though they were going south for the winter, so I suggested that they use this device, a portable consumer device that produces very good vibration at 40 Hertz and that had on board a sound or music, in fact, the piece . of music you heard in the middle after the crickets that has a lot of low frequency at 40 Hertz, so you used it for 30 minutes, you would have 10 minutes of 40 Hertz sound stimulation.

I suggested they use it every day. I met the couple three years later and my first reaction was: I really can't say that this woman has Alzheimer's, so I asked them if they would return to the hospital to be reevaluated and if we could complete the case. The case was just published last July and what we found when we reviewed the case file and the evidence was that she had exactly the same MMSE, this standardized Alzheimer's score three years later, that she had when she was first diagnosed, so We have high hopes that we can potentially reduce the impact of Alzheimer's development, we may be able to slow it down even if we can't cure it, so we are planning another study now where we will look much more intensively.

In the mechanism here with images of Emmie G's brain, we will also see amyloid beta, which is the plaques and tangles because a study at MIT almost a year ago showed that a 40 Hertz light flickers in the room for 7 hours of just blinking 40 Hertz in the room reduced amyloid beta by over 50%, so we're going to compare that to sound stimulation and we probably hope that sound stimulation will also reduce amyloid beta and, in that sense, help reverse the basis of Alzheimer's, just for the record. here are some posts let me tell you below about a case that came to us for fibromyalgia treatment.

She had been diagnosed with fibromyalgia about six years earlier with a severity scale of about 17 out of 20. She had many of the classic symptoms. She was in pain all over. about her body while she was taking medication she had real trouble sleeping she was depressed she had a stiff neck and shoulders she couldn't sit or stand for long at a time she missed a lot of work so we gave her a prescription for 23 minutes of stimulation 40 Hertz sound twice a week for five weeks on this device, the next neuro lounge has two transducers and what we discovered after five weeks was that she had stopped using all her medications, she reported that she was sleeping much better she was less depressed the chiropractor checked his neck and shoulders and he had more mobility he missed fewer days of work and then the question is why 40 Hertz sound stimulation would have this result in fibromyalgia many doctors just say oh it's just all in your head it's often diagnosed as a psychological problem.

I think it's all in your head or at least a good part of it is in your head in terms of brain connectivity because research shows that fibromyalgia has connectivity issues between parts of the brain and then the pain circuits, so the theory would be that our assumption was that 40 Hertz sound stimulation would restore this connectivity and she showed that there were positive results, so we then did a study with 19 patients who completed an open label study and the prescription was the same. like hers 23 minutes twice a week for five weeks and what we found is that before the treatment began the patients tended to cluster towards the negative side of the scale, the right of the far right and at the end of the study they were The positive side of the scale, what we found was that a quarter had stopped all medications, we had to reduce the medication and we got a positive response across the board, so we then went on to do a randomized, controlled trial. , double blind, much more rigorous, with the Mount Sinai prescription. here it was forty Hertz for 30 minutes a day five times a week for five weeks, thirty-eight patients completed and we used this same Oasis sound device but with an mp3 connected to the treatment track and what we found at the end of that study was that Again we saw a significant reduction in fibromyalgia symptoms and 52% of patients' symptoms improved by an average of 40%, so some had considerably more improvement, others had somewhat less.

The next study that is already funded will again use brain imaging and in this case I will also do a blood draw to observe the effect on proteomics of gene expression and inflammatory markers. I can't talk about all the interesting applications that we are looking at now with major depressive disorder that initially had very good results, my colleagues. at Laurier University have done some good studies on Parkinson's. My colleague at the University of Toronto has even shown that vibration can increase bone cell density. One that I'm excited about and am just starting to do is blood flow, dr.

Arkady Yuri Ash in Miami has done pioneering work on this and has developed a device that can be worn on the wrist or chest, so we are using a sound that I created in a studio in Los Angeles to reduce the impact. of stroke with sound stimulation, we are simply working on our proposal to reduce the risk of heart failure. In the next video, I'm going to briefly show you how quickly this effect occurs, so at the beginning of this video we've got the cell phone type device attached that size to this person's risk the wrist the blue indicates a normal blood flow

level

and once the device is turned on you will see very quickly that the yellow and red will increase as the blood flow begins to increase in this In this hand, this is an area ofresearch that we're just starting to do intensively and I think it's really promising for some very serious cardiac and blood flow treatments.

Fifty-five years ago I was working sticky and sweet listening to crickets. in the honey house and could never have foreseen that the questions he was asking about crickets and belts could become musical

medicine

. I couldn't have foreseen that the idea that came from this cricket could begin to create a sound that could impact the cells of your body. that stimulating cells with sound can reduce the risk and impact of health problems such as Alzheimer's and Parkinson's, fibromyalgia and depression, but what I do foresee now in the not-too-distant future is that when a doctor encounters something like Alzheimer's, Parkinson's or depression, they could take out their prescription pads and write a prescription for sound stimulation and that's musical medicine at the

cellular

level