High-flow nasal cannula oxygen therapy: An effective treatment option for COPD

welcome to the blue briefing, our video will discuss an important article in the american journal of respiratory and critical care medicine. Here we discuss home

oxygen

therapy

with

high

-

flow

nasal

cannula

for stable hypercapnic COPD. A randomized trial by researchers in Japan on chronic obstructive pulmonary disease, or COPD. A group of inflammatory lung diseases characterized by air

flow

obstruction and breathing difficulties in their advanced stages, COPD causes chronic respiratory failure that is often characterized by hypercapnia or elevated levels of carbon dioxide in the bloodstream, which It can eventually lead to chronic hypercapnic respiratory failure. Associated with repeated disease flares and

high

mortality rates, patients with chronic hypercapnic respiratory failure in the setting of COPD may require long-term

oxygen

therapy

to maintain adequate oxygenation, but in this new study, the researchers compared the

effective

ness of long-term chronic oxygen therapy. of long-term oxygen therapy when administered alone and in conjunction with high-flow

nasal

cannula

oxygen therapy or a high-flow system that delivers heated humidified air through a nasal cannula with supplemental oxygen and can be used at home for this purpose. end 104 Patients with stable hypercapnic COPD defined by daytime arterial carbon dioxide levels greater than 45 millimeters of mercury in patients with Gold stage 2 4 COPD were randomly assigned to receive 52 weeks of long-term oxygen therapy alone or with high flow, the study found. that patients given long-term high-flow oxygen therapy had fewer moderate and severe exacerbations.

The primary endpoint of the study, specifically subjects treated with long-term regular oxygen therapy, had an adjusted odds ratio of 2.85 moderate-to-severe exacerbations relative to high-flow subjects per week. 52 of the study, 36 percent of the subjects treated with long-term oxygen therapy remained exacerbation-free, while 56 of the high-flow subjects were exacerbation-free, they also had significantly improved health-related quality of life scores and an improvement in peripheral oxygen saturation of 1.2 percent improvements in pulmonary physiology also occurred, but was modest; Furthermore, no safety concerns were observed with the use of high flow. While this article does not identify the mechanisms underlying the improvement seen with high flow, the authors hypothesized that they could include improved clearance of secretions due to improved humidified mucosal air. elimination and decrease in muscle fatigue due to overall better ventilatory efficiency, these observations suggest that high-flow oxygen therapy is a safe and

effective

treatment

option

for outpatients with advanced COPD.

For more details, read the article by Dr. Kazuma Negata and his colleagues. Thank you for viewing the blue report.