Bryan Johnson | Blueprint Rejuvenation Athlete

Hello everyone, welcome to the flossites health and biotechnology outreach group, a sponsor with over 100 capital. I am very delighted to have Brian Johnson here today. Brian and I met maybe six years ago or something in San Francisco and Maya, Lockwood, was the one who introduced us. We and you joined a recent faucet Vision weekend at the time which was mainly focused on the Colonel and today we are here to mainly discuss other things, although they are not entirely related to the Colonel and I have read some of your um. It's like you know more long-term philosophical works and it really seems like between the plane and the core it's a straight path, I like the pretty, I think it's ambitious for civilization, and three, Randy, so I think it's really very , great that we can chat, thank you very much for connecting.

I think just in terms of timing, there couldn't be a better time to do this, right after all the kind of, you know, recent discussions on Twitter about uh the. leadership board of longevity leaders, etc. so I think it's really cool, I think trying to connect, thank you so much for connecting. So his work specifically on

blueprint

has been circulating within our community for quite some time, um, and people. You know, you hear that a lot of people in this room, but also generally in the broader community, are relatively vigilant about the way that they know they track and measure their own health and try to improve it, so I think that was a really welcome yeah a little bit of information for you guys to get and I really commend you for being so thorough about all of this but maybe for someone who maybe doesn't know what the blue trend is all about and could maybe give a little overview of the

blueprint

and what led them to the work they are doing with it.

I have my pilot's license. First of all, hello everyone, it's a pleasure to be here. I got my pilot's license a couple of years ago. A day ago I was flying the plane and I turned on the autopilot and it was such a cool feature that I had become familiar with all the different instruments inside the plane and how it measures what's happening and then makes automatic corrections and makes such automatic micro-corrections that keep the stable plane to a much greater degree than I could make it with my own hands. I would watch, try to fill the plane and see how it moved and then make these corrections, but again it was no, I couldn't. compete with the quality that the plane did and I asked myself at that moment I thought I could build an autopilot for my body that I have this really crude way of doing things if I do this and that and I feel this way and I can seeing the weight go up and down, but I really miss the more granular changes in my body, so I contemplated that question for a while and then I got down to it and now the team is a few dozen people and their specialties. in various areas and we try to measure everything we can, we try to match that with the gold standard scientific evidence and then we create protocols to do that and what I agreed to do in the program was I basically said I would like to create this program so that I take the best care of yourself that you can and that's going to require me to say that I'm within the protocol and I just say yes to everything and that means that you're going to change some habit or some social practice or something like that.

That's how I'm going to do it and that's what I've been doing for the last two years. I just follow the data and I follow the evidence and a lot of times we're in the unknown where we can find a little bit of data. and a little bit of direction, but we just went with it and it's been fantastic, so I spent a lot of money on this and shared it openly. I didn't share everything, but I shared a lot of things with uh publicly because it's very difficult to do this, it's very difficult to bring people together, it's very difficult to find people who are willing to do this, so I hope it's useful for people and they can accept it, approve it and promote it. yeah I love how I think you are and one of your first posts right at the beginning you say you're fired for the night Brian because it ruins most of that morning's work that Brian needs to accomplish and I think that's actually , I like understanding number one, I think you eventually get to that, like there are different parts that don't always cooperate with your long-term goals, but yeah, I mean, could you maybe explain a little bit more about how if you knew the something as well as Prince, if there are some that you already know, they are really principles that have emerged over the years that you have been doing this work and what they are.

I think you list about four general principles, um, you know in your writings. but maybe there are more since you last updated it. I would feel very curious. Yes, one is the basic observation. I mean, this is a group that is very familiar with and enjoys technology, so as a technologist, I enjoy building with things. where when a given iteration is built, it becomes stable and reliable and won't make mistakes, it will just do what it was designed to do and then that thing can be improved to the next version and the next, but you rarely go back from a V4 to a V1 in terms of its functionality, the bugs may seem good, but generally the gains can be amplified and that's not really true with humans, we have this tendency to engage in simply self-destructive behaviors, so we do things that are not what's best for us we eat too much food we eat too much of the wrong food we can smoke we can drink too much we can have all kinds of bad habits and even though we know these things are not conducive to well-being they accelerate illness we get older and may not be conducive to our goals In the long term, we still do them thousands and thousands of times in our lives and I don't know if we look at this from a futuristic perspective, is that right?

They normalized these self-destructive behaviors that they were not aware of, in fact, we celebrate it, if a person does not want to go out drinking with friends and stay out late, they are like excluded from a group for being a party pooper and So we just have this culture and norm of these self-destructive behaviors and maybe we would say it's kind of crazy as a species as we think about how we move into the future and then, yeah, so I'm Trying to draw these basic principles of the entire plane was this idea in the that I've been thinking about for a decade, which is that we are in this special moment on planet Earth with the rise of technology.

Where do we go as Species like this is the question I think about Non-Stop and there are two ways to do it: one would be to point out all the things that need to change the world or improve or whatever, the other is the point itself and I thought that might be the most promising starting point: looking inside myself and saying how I could really achieve the future I want by first dealing with my own internal goal alignment, but as you work with related nutrients, then with your professional . The run that you had with Corner I like to kind of uh get out of that um or you know, it was more of a personal search on the side that eventually also turned out to have a lot of relevance to uh, yeah, before working with the kernel, which It's mainly, you know, in the new attack, everything is interconnected, so the basic question once I sold Braintree Venmo, uh, I had $300 million and it was this question, where is it? singular thing that I can point out and do that would be useful to other people from time to time in the distant future, so I have been working on this puzzle for a long time while I thought about it more, it seemed to me that focusing on improving human beings , improving ourselves, could generate unusually high performance benefits, we spend an enormous amount of time building our own technology, we spend a lot of time talking about solving big problems, not so much on systematically compounding growth of ourselves, and that's why when I thought in the future and it seemed to me that the biggest problem we have is that we need to figure out how to cooperate or align ourselves with the objectives and that is that we are within ourselves with each other with artificial intelligence and with the planet Earth, so basically it is a game .

Of billions of intelligent agents we need an alignment of computational goals at this scale that we haven't had before, so the experiment with blueprint with myself was basically a question like we've heard about this with AI like we heard the discussion about oh , we need AI to have goals aligned with humans, for me it is a bit silly statement because it presupposes that humans have the same goals and that is not true, even within us we have different goals, so no one is aligned in nowhere at any time, so I had this question: Can I follow a line even within myself?

And that's when we started taking this approach. Could we start measuring each organ in my body by asking it what it needs to be in an ideal state? Looking at the evidence, designing a clinical guideline. implement the protocol, measure the protocol and repeat, so you are asking all the organs and all of Brian to cooperate, so it is actually the first time in my entire life that I have been able to achieve cooperation within myself in all the other states of my life. I would say that the level of turbulence I experienced returning to the plane like Jocelyn felt is substantially more of my emotions and thoughts throwing me back and forth.

It's the first time in my life that I really felt settled and stable as a person. I think it's really interesting, since there's a lot of, I mean, Marvel Minsky, you know, in the past, said this idea of ​​Society of Mind, um, basically we're even internally, we're so divided. and we are so conflicted and we have different agents in our similar mind that want different things in different periods of time, so usually when people think of an alignment of internal goals, I think of something like in philosophy, maybe like reflected for the balance where I bring you more belief, I'm sure, like a balance or something like meditation, but it's really interesting that you literally try to do this physically, um, and yeah, and maybe we can get back to the question about AI, which is what I think.

I'm really very interested, but just for now to update people who may not have liked to digest the amount of information that you put online there, but, yeah, could you maybe go into a little more detail about what's that? you're actually pretending you have some steps with you that you know start with measuring meal prep supplements and all this kind of stuff that people here are really interested in, so if you know that, could you paint and draw? as Broad teases a picture of what he is, what he really is, what blue tail means, and what the blueprint implies for him on a daily basis.

I loved your summary, you're absolutely right, uh, how you captured what we talked about earlier, um, yeah. So the plan is basically, uh, it's trying to solve a problem for me and everyone else. Usually when a layman gets involved in health or anti-aging, they will first quote, they say eggs are bad for you and then they say eggs are good for you or maybe it's the other way around and then they say no one knows and they give up, so there is this general perception among many people. I think we all experience this in life that it's hard to pinpoint what things work and why. and how to keep it stable and how it interacts is very difficult, so the blueprint was an attempt to say here is a version that can do something useful, it doesn't mean it's the best version or the only version, it's just one version and here there's all the data that we can acquire from every possible measurement Source on how it's working and, for me, the data that I find compelling, so if you look at my biomarkers, I have over 50 perfect biomarkers in the clinical outcome range of obstacles.

I have 100 biomarkers at least. than my chronological age using the denuded epigenetic marker and Pace algorithm. My 18 rate is 0.76. That's the algorithm it has. I think the higher correlation with phenotypic markers has phenotypic results. I have a 5.1 year age reversal using six epigenetic clocks, but let's say we throw out the epigenetic clocks because let's say they're on the rise, you don't trust them, but take them with a barrel assault, if you take my biomarkers and look at these other things, Generally speaking, it forms a picture, although you think that my fitness tests, what I do, like VO2 max. and you take my stretching and my good strength and all the other things, it's usually a picture of good health, huh, and that's why I'm supposed to tell someone, here's the entirety of what I'm doing, you can start with this as your way into this game and then you can improve it by your own measure, but potentially it helps overcome this paralysis that most people think exists because with paralysis most people say well, I'm going to follow the ketogenic diet or I'm going to follow the South Beach diet or I'm going to do it.

They want to find something that isstructured and gives them a plan, so what this means is that here's a stable place for you to start and then you can make your own version, but again, it's really trying to advance the field in a systematic way and it means If you have an opinion, share data, let's not be left hanging. in the opinion land of this tribalism of vegan versus um, you know, meat, uh, let's use data to have conversations and it would help everyone move forward. in a more structured way, very cool, yes, I love this, certainly It's, um, I think so, one.

I knew that this group, uh, is very extensive, would you say that you yourself have had to find crazy surprises? I remember. For example, when I underwent a glucose monitor, I was surprised at how little effect alcohol had and how much effect tea had, like tea with a certain sweetness, etc., so I think it's different for everyone, obviously , but like me, I definitely had it. I was also surprised by something. I thought this didn't make sense to me at first. Was there anything that seemed incredibly surprising to you? Not to say that this advice is not for everyone, but for your own body.

What was something you had to do? let it go, yeah, I mean, the thing that surprises me the most is actually the one that's been sensationalized in the media, which is this high frequency electromagnetic stimulation and people were talking about it for nighttime erections, so I didn't think This will be shared publicly. I didn't share it to publish it. I thought it was sharing and trusting, but it turned out to be kind of fun. We had this very famous machine and we used it. because it makes muscle contraction and we thought it would be a fun device to play with and as you age your pelvic floor ages, many women use this postpartum to help with a variety of issues and because the device had this thing. that could help build my pelvic floor.

I thought wouldn't it be cool to experiment with this to see if I could avoid getting up at night to go to the bathroom because on average I get up once a night which is normal but every time I don't get up to go to the bathroom I sleep substantially better so I was just trying to solve the problem of not getting up at night to go to the bathroom and surprisingly when I started doing it. This, I had this other side effect that you know is like sexual health and there are actually age curves in nighttime erections and duration and frequency and all that, so it's a bit of a taboo topic to talk about in the life because normally you are going to hang out with vegetables, fruits and other things and these are things that should not be talked about, but I guess it is something that you should try to be open about.

We're exploring a lot of things we're trying. To do it systematically we experience these surprises, um and you know, of course, it didn't hurt that that's something that people led in advertising because it's something that a lot of people think about and worry about, and so I. I would say that we experience those kinds of surprises all the time and data really is much more insightful than subjective experience, so you know this, obviously, you know to some extent that it started with you and then recently, you've really liked it. You know, you've talked a lot about trying to enroll more people like yourself in programs like this and just to get a little more, more data on the table.

Could you discuss a little bit how you know how that works? The journey began with you doing this individually as an extraordinary effort on yourself and how you are trying to bring this perhaps to the Public Consciousness more so that you know the Public Consciousness or at least that within the sub-communities that I have heard of, such as different groups, not just within our community, but like other different groups that care about longevity, you know, everyone has recently sent these few gifts and we thought, hey, this is what we should do internally in our group, so you definitely already know.

It's taking hold, but yeah, what is this kind of effort like you're trying to get a little bit closer to the public consciousness with the leaderboard and stuff? Could you explain it? Yes Yes. I guess there are probably three things. The highlight is that there will always be an infinite, infinite depth of debate about certain things, so no matter what one person does, no matter how much data they have, there will still be dozens and dozens of different opinions, so it won't resolve anything in the short term, but that's productive for people to take this up for debate and then be able to do their thing, so one is, um, it's meant to start a conversation about the rigor of measurement and then the number.

Two is, hopefully, that rigor can be transformed into a competition, which is why we launched the Rejuvenation Olympics. It's very easy for a critic to jump on the scene and use words to try to persuade people of the pros and cons of a certain thing. It is much more difficult to present. Is much more. It's difficult to share data that has the same value in its contribution and you could say that the Newton Pace algorithm is good enough to be a rough measure of how someone is doing if you want to say how I am at full health rather than looking at 50 different biomarkers and doing a blood draw and all that kind of stuff, just a number, what's the speed of Asia in my body?

It's interesting to start a conversation with myself and others and how you're doing. to turn this and this goes back to earlier years as an entrepreneur. It always seemed strange to me that my fellow founder of friends would want to go out at night and have fun and stay up late and then the next day they would be doing really important things in their companies making really important decisions and all that and I understood it because I considered myself an

athlete

. professional, a professional entrepreneur and my brain was my most precious resource and being in a good place was going to be valuable and So in this I've used the I'm a professional

rejuvenation

and

rejuvenation

athlete

framework, and I take it seriously.

I behave like an athlete. You know, if I go to bed on time, then it's like an athlete is going to spend. In time before a big game day, we all support and stretch ourselves to perform, but right now we don't have a culture that honors someone's devotion to their craft and they're really going to prioritize sleep and diet, so this wants say if you are serious about this. You can be a professional athlete if you do it. You will have coverage. There are many people they have spoken to. You know that they do many things for the health and well-being of their members.

You're killing me like stop, it's too much and then they say, well, they just send the link to my website like, but you know what could be a lot worse, look at this guy, you know you could be with him, but he gives you. people cover that to start doing things that kind of way and then I would say three again, is that a conversation with data is the best way to move this forward, it will resolve debates faster than verbal arguments, so I think which has the ability to push the Tilt forward faster yeah so in this leaderboard basically it's like you really know that people share different yeah different ways that they correctly measure their longevity and then they're also a discussion forum where they can basically discuss like, hey, I'm on this particular diet or it's going to be mostly like, hey, no, I'll leave this with whatever you know, individualized, it's asynchronous, um, it's discreditable as an intervention.

I'm doing as you know. Are you trying to like it because they say it's a conversation starter? So eventually I don't know if there will be discussion forums like houses. I mean, that's the hope that everyone shares data, yeah, that we become a community that helps everyone move forward and that's what the Olympics are about. If you, a person would be motivated to be at the top of the leaderboard, but would also be a contributor in the community and share what they are doing. It is very interesting, so you will like it individually if you wish. to give people a head start in this race, um, what have you found?

You know we're the most successful intervention you've been doing in your diet, exercise, etc., like someone comes along and says, "Okay, all of this." It seems like too much for me. I'd be interested in the MVP version of this and there are some specific things you're good at. These had really big multiplier factors, so yeah. Self-destructive behavior is probably the best. What you can do for your well-being, I mean, it's funny because I think we all know this from experience, when we do positive things for ourselves, for example, go to the gym and exercise or something like that, that day we are more likely to Do something wrong. for ourselves because then we think, "Oh, I can," because I went to the gym this morning.

I can have a second helping of lunch or I can have this brownie or something like that. So human psychology is a lot of fun, but let's stop being self-destructive. behavior is probably number one and then sleep is probably number two and then eating more vegetables and berries and nuts is probably number three so just the basics of things that we all know so have you found different ways to reward yourself because I think it's usually the way that we think of rewarding ourselves is for things that you know are guilty pleasures and then you've found ways that really work where you then feel satisfied that you've rewarded yourself or that you've done something good for yourself. same because I think it's a It's hard to figure out, yeah, yeah, the responses to this have been amazing and I mean, I guess I've hosted a brunch at my house.

I often call it the first dinner and we discuss philosophy and the future. Being human does it in a structured way and I have done it so many times. Now I know these predictable responses and that's why most people, when they see what I'm doing, make a comparison in their minds and then identify everything in life. I couldn't do it if they were into this, you know, so it's like my special Saturday night pasta dish or a glass of wine or my I know what they call their 15 or 20 different things and they immediately conclude that I don't believe. can exist without these things happening like it's an existential crisis where they can't imagine existence without doing these things and that's why many people you know alive said they basically would rather die than do this and those things are not true . just humans responding to change this is how we deal with change when we see something that is different than what we are used to today we call it names we call it dystopia we say we would rather die but in reality those are not real representations of how we think we have failed, they are just new idiotic reactions and that's why I've never been happier.

I have never felt more fulfilled. I have never felt more rewarded. I have never been more stable. I have never been. in a better place and it's funny because the reaction is that people assume that I'm miserable, that I just have no joy in life and that I'm a martyr for the cause, so it's funny how people you know perceive, I guess so If I don't feel that way, you might feel uncomfortable, but it's been fun to see how people perceive my situation and what they might feel if they did it themselves and changed significantly. I guess it was like that.

It's not the case from day one, but after a while maybe you reach something like escape velocity and it was easier to do, maybe for that too, probably the measure, um, like actually seeing that you're making progress, like um, yeah, could you, um, maybe? It would be interesting to talk about that, like how much you reduced your biological age after a certain time because I definitely think that's a great carrot to hold up in front of people's faces if they're trying to do this kind of thing, yeah. "Of my friends and family who are in this, they go through the same stages, they feel intimidated, they get involved, they say: hey, it's not that bad, then they love it and they can't live without it, and I almost can" .

I don't think of a single person who hasn't had that experience, everyone comes to the same place, life has never been so good for me, they feel great about themselves and it's just the process of going through it, but usually I mean. I think we all recognize when we feel and look our best, you know, that's when we're happiest, okay, very nice, a detailed question would be like, how did veganism come about, which is significant, I think. you know, it's part of the whole diet and it will certainly be a surprise or like another store on top of the other surprises for someone you know, a little bit diabolical with that, uh, yeah, veganism, it's like that.

I still eat collagen peptides. how I have lost my collagen peptides. I'm trying to find a vegan version of that, but outside of collagen peptides, yes, I'm vegan and it's a choice, not by necessity, so the blueprint doesn't say anything about meat, I mean, anyone can do it. It's really a system, it's the implementation of measurement protocol guidelines, so, yes, it's really by choice, okay, wonderful, and also do you have more ambitious plans like, for example, blocking the methodof the plane in the Olympics method of longevity you want? being first in someone separately, uh or independently or as you know, I guess you know that the blueprint method is already inherent to the longevity Olympics method and that's your best guess as to how you could win these Olympics, but are they there? any kind of how do you know the future I don't know I guess more um kind of how do you know yeah more solutions where it's basically like people basically share data the same way you share data with blueprint like everyone uh that gets into these at throughout the Olympics their power these two products are related in themselves, that is the hope I mean with you Olympics of rejuvenation I did this partly because, like my parents, their level of knowledge is if they go to the doctor, the doctor will be Okay, your um, your blood glucose level is high, you know, we need to work on your cholesterol, they will make these observations and then my parents would leave with this general understanding that there are some little things that get busy, but it's okay. and health, but there really wasn't an easy way to say if there's a single number that explains how I'm doing because cholesterol is important, but it's not a single number that describes every cell in the whole body and therefore with the speed of aging. a single number that my mom or dad can understand and say what is your number, what is my number and how my number has changed, so Newton Pace has been shown to respond to lifestyle interventions and so Therefore, with calorie restrictions there is good data in this regard. and so it's intended to allow it to be used in small talk, in the same way you would exchange information about the weather or how you are, you might exchange a point-blank number or a blank spot on my speed. of aging and everyone understands this context, so it's really meant to make it commonplace to understand your biological systems as a whole and the details can go on about cholesterol and triglycerides and all that kind of stuff, but it's meant to be as we know how much money is in our bank account, uh, how much we weigh, we all know our rate of an aging number, for example, yeah, and I love that by posting one as usual, I think the best way to get better measurements is to put one out there that's suboptimal, you know, but so far your current best guess and then other people say no, but I actually have this number, but at least you're like at that point you're like selling that field of game like, hey, now we're talking about a number, uh, which is a really interesting approach and it's definitely something that I've seen sold in our communities for a long time, but it's really cool that someone is just creating the spotlight like , hey, I just did this and from now on here and that's a conversation state.

Before we move on to the audience questions, I have one more and it's like maybe more long-term. It's kind of a question like you know you have a plan, you have a core, now you have this Rejuvenation Olympics that you've written a lot about, like your broader philosophy and your plan for Humanity and you're really making ourselves literate. about what is possible for us individually what is possible for us um you know, kind of on a more human level um you talk, you know all the way uh and you get into the new economic incentives that we can have um you know the fact that we're willing to embrace AI and so on, even down to the existential risk and the fact that we need this global immune system, so you know, I think it's definitely super encouraged in the sense that you know like they are us.

We have these different groups within our Institute, they're all working towards this kind of larger development for civilization and I'm very curious, like you know what made you start this pretty big mission and how you see, you know. You work a bug when it's kernel and now these Olympics like to fit into this kind of Bigger Vision that you have for yourself recovering in Civilization becoming healthy and happy. I love hearing as does United Vision about this and before we get there. with more detailed questions and answers. I've read a lot of biographies and I enjoy biographies because you get a first-hand perspective, a point of view on the events of a certain time and place, so not a historian. necessarily talking about the things that you understand the person through their letters, their old words and their own diaries and in these different biographies, one thing that was interesting is that the people that I really admire is that in their time and place they serve in the panorama of all possible. things that they could identify and sometimes they point to the Horizon at something that you can barely see and they say we're going to go after that thing and most people can't see it and most people think it's too hard to go after and these people, for some reason they have this idea that the bold have to say, let's do this and they slowly push this forward, so if we ask ourselves the question right now in 2023, let's try to get together, let's try to turn down the noise as much as possible, let's leave our mind as clear as possible and let's try to evaluate what is the horizon that we can aim for at this moment and the framework that would give is, you know.

Talent hits the mark that no one else can reach. Geniuses strike. the goal that no one else can see, so what is the horizon of opportunity that no one else can see? My argument for this is that we are in this special time and place of the species, it is time for us to get serious about our evolution. It begins seriously and ironically. I like what Alfred North Whitehead said, which is that civilization advances automated by the amount of automation, a series of important operations that can be automated without thinking about them, so when I think about my autonomous self and automation, the help is basically perfect.

For my body, wouldn't it be great if everyone in society had perfect health? So we just built this layer where everyone had it, it was measured, we had a protocol, we had data and it was just a standard and we raised our thoughts to say now. What more can we do as a species? You know, instead of fighting this right now. It takes a lot of our time and attention to address our bodies' nutritional needs and we're not doing a great job. I mean, I know. This algorithm that I built the model is much better than me at taking care of myself, so you know, I'm not in the business of taking care of myself anymore, this algorithm is not doing it for me and it's superior in every way and I guess that's really what I would say, I think it's time for us to look at this and pursue it and there's a role that you see, you know, for example, colonel or like in General Neuroscience Game because I know you're already taking into account some brain data, um, in a big way, anyway, but, as you know, I think over time there are a lot of things that we could also be doing to optimize our tastes. mental health and as you know, we really like to optimize our cognitive abilities, so do you see it as another stepping stone and yes, and maybe as you know, also being able to generalize a type of data analysis through more advanced AI tools, How do I believe?

There are so many possible things you can layer in the stack and it's really nice. I think so, go ahead and do these more advanced things too. You're right. I mean, Colonel is a wearable brain device, so in the same way. Many of us have experienced wearing aura or scream or any other Apple watch, we create intuitions about our sleep and our resting heart rate and all the above that we see when we eat late, we have this type of sleep performance when we drink. To have this kind of performance, we develop intuitions, the same with blood glucose monitors when we eat food like bicycles, so we don't need them perpetually, since you build these models to understand this measurement protocol, we don't have it to the brain at this moment.

We don't have any quantitative way of acquiring high fidelity brain data that is easy for our brains, so we can't calibrate our brains and our minds in society in any way, so yes colonel, we have built the technology that took us five years. uh many thought it was impossible to do it, we did it and now we are at this critical stage trying to prove that we have two studies that we published last week, peer review studies, one is that we looked at 15 healthy people who took ketamine in the Otherwise, we did it with 48 people who did not take low and medium doses of alcohol and we are basically trying to develop intuition of what happens when someone takes ketamine.

So I was a pilot participant and I have data on myself from doing it every day for five days and then I studied the Academy 30 days later, so what happened to my brain over a period of 35 days is really interesting and the same occurs with alcohol and impairment, as we compared this to behavioral tasks, so we incorporated them into hope. to build intuitions that we can now ask questions, what happens when you insert an answer, you know, the brain dungeon, so hopefully we can test something specific in the market in time. You take this to the market.

That's really cool and congratulations for using yourself as a guinea pig um okay wonderful we already have so many questions prepared it's a little crazy at this point so I'd miss it if I didn't start taking some of them so I'll ask Nikola to maybe unmute first if he wants. to give a word of background like you know how you got to this question or what your background is and for Brian to have a better understanding of how you know you're like I guess as a technician the technical level at which Answering this question would be helpful and yes , thanks Brian for a great talk and I'm always excited when people move from neuroscience to longevity and in the other direction, that's a shared background we have.

Thank you also for being the Daredevil. of longevity, so the question I have is maybe you can solve a problem that we all have: we have nine seals and soon they will reach 12. It is a multifaceted problem that we are solving and most people and that is because In system we can only test one element at a time to apply a therapy that is specifically aimed at one of the longevity problems and obviously that will not allow us to escape the Lost, so how do you address synergistic effects? From a scientific point, the integrative effects of multiple interventions and especially in the long term because as an audience, some people around you and everyone talks about Mendelian randomization to see causality, but those things go a little bit beyond what you are dealing with. resolving. a problem something that you know is going to be with you for 20 30 years how are you approaching it yes, I agree with you on the goal I agree with you on the problem of the end of one specifically what I'm doing no I think we have a assault.

I think the team is doing everything they can to manage the protocols for measuring the speed of progress and sharing the data. So I don't think I have a good answer for you other than we're doing our best thing with a very small team and trying to move as fast as we can, we hit some really big roadblocks trying to do things that are very difficult. , like for example, we are doing a whole body MRI protocol right now. trying to get every organ in the body in a routine measurement, uh, it's been very difficult to find an MRI center to have the right MRI machine, you know, to have the right radiologists, that's how it is and then it's reads as if everything turned out like this. difficult, so I would say that for your question, we are probably failing you in what you want to see, it will be my assumption on the identity for the second question, yes, so I also do biofagi and I chose a different perspective.

Looking at the microbiome and I'm looking at the immune system because that's where most of my work is and I also lowered my age, we have the same calendar age. I also lowered my biological age by about the same range in these other parameters, so the question is when we jump around when we talk about escape velocity, do we really think that our overall biological age has been lowered at all? Is it like we know the kennel token in the stock market or are we working on a specific element of our age which is the one I'm optimizing for, but that's just one of many parameters.

I agree with your question, so AI means open, right, to be determined. So I agree that it's something we should explore. I guess it's also something that will emerge, you know, based on many more. people doing specific parts and specific interventions and then, finally, you know that youyou may like the cross comparisons between the editions, yes, I mean Nicola. I think your questions are great. I think they highlight areas where our project falls short. I think we just don't solve, you know, critical things in the field of aging, it's a contribution in some ways, but it's not a silver bullet, right, it's a data point, but it's not conclusive, so it really is in this one. point, I think the usefulness is.

The idea is to get the idea out to more people that you can do something to improve overall in a reliable way and that if a person does something that he can trust, it will be positive. I think that's really the small step we're trying. take, I mean, outside of that, I think that would be overstating where we are now, so I think your questions, Nelly, are great, okay, next we have Lauren, hey, Ryan Lawrence, from beating him here. I'm wondering if since you're interested in an impact on your own longevity, as well as having an impact on the world, doesn't it make more sense to have this kind of expert principle, like maybe making 10 or five percent of the effort for 90? or 95 of the potential benefits uh and then use that energy of yours and resources for more uh focus more on innovation and therapeutics uh and the rights of biotechnology or nanotechnology and also just the diagnostics because I don't think the diagnostics that we have now They are very good and so it is really difficult to know what to optimize in terms of lifestyle.

I think you have these biological age clocks right, but we don't have the incredible longitudinal test with an interventional arm to really know what's causative and we can predict. morbidity and mortality, etc. Yeah, I think I'd love to hear more about how you think about therapeutics and biotechnology versus focusing on lifestyle. Yeah, I mean your question is basically about capital allocation, so if given the right time and attention, yes, yes. capital in terms of resource allocation, you know, I've been working at Colonel for seven years, so I spent five years investing $100 million in synthetic biology, genomics, computational therapy, for example, as first career money and Ginkgo biojobs , and that was my first experience seeing deep tech of what it takes to bring deep tech to market and then I did it personally with the Colonel, so I've been doing it for the last seven years having the first -I have experience trying of bringing deep technology to market and then I have experience with blueprints for doing this and they are different resource allocation models and everyone, of course, is always trying to find the power laws of life.

I'd love to hear your opinion. Thoughts, what are the power laws of longevity? You know, what if there are power laws that can be identified and that can allocate resources. You'd love to know how you delegate at Capital One Time. I'm very interested in my own longevity, right? And, but I'm definitely spending five percent of my efforts on doing personal things because, again, I'm pretty disillusioned with how we just don't know what works and the biomarkers that we have now, like you. I think the plan is really the best one so far, but we still don't know if it's good, right, we still don't know if we can predict morbidity and mortality accurately.

Yes, we still don't know if that's the case. We're doing the right thing so for now I'm definitely focusing more on biotech and betav as well, obviously we have this great community, we could focus a lot more on lifestyle but for now it's not as rigorous in terms of It's really impactful . Therapeutics could help us stay healthy much longer without a disciplined lifestyle, even if it was perfect, we would still age and still generate eventually, so we definitely need therapy. No doubt, yes, I agree with your question, how does it stand out? Basically, in this field right now you know there are thousands of people testing their own model, their best estimate of resource allocation, whether you're in academia or whether you're building a company or whether you're doing this personally, everyone is running this algorithm, no one has cracked it yet.

The blueprint is a version of the research assignment, so you take it for what it is. It is an attempt, whether it is valuable or not. TBD, but I thought it was a missing variable in this game. When I get on the field again, we will see over time if it is a good or bad decision. Wonderful thank you, very good, we have two juices, thank you Brian, thank you very much for being here. What have you played with that doesn't work? and uh, what haven't you talked about in a more public forum that you feel comfortable in, perhaps pointing out here?

So, you have a little bit, uh, you know, a five-point cenolithic on your plane and other things like that, etc. the statinib and, you know, thank you, I love learning from you, we as a team, we've been this past week, we've been talking a lot more about what they share publicly because you know, we, we've been doing this. With rigor and seriousness we have also been having fun and the attention we have received has created quite a few responses and from serious scientists we usually get angry, you know, they, you know, want to beat us. a little bit and so we're thinking very carefully about how we do things in the future and what level of peer review we're going to do because there's a strong appetite for, you know, for a wide variety of things, so we've done a lot more than we've talked about publicly and at this point we just need to think about what we share and how we share it because there is a broader community involved in this and we are trying to be aware. be good participants very well um, that's a very diplomatic answer.

I like it and excellent. We have Carl. I have a big question and a small question. The big question is: do you know? We have many forums on the web where people discuss biomarkers. biomarkers and also their longevity stack um individual interventions um there aren't many good forums for people to discuss the whole giant effort like blueprints um do you think you know that it's part of your plan to not only publish it with your data but also to try to form , you know, leading a global conversation about the full stack, you know, getting into the weeds, like optimizing it, you know, debating each individual part with qualified and knowledgeable people, there are other people doing things vaguely like you, but not so integrally or perhaps. publicly, but like Michael Lust Garden, for example, and there are a lot of us on this call, but we are doing things, yes, I'm curious what your plans are on that, but the little question is also the device that you mentioned, actually also reduced the night? bathroom visits, yes, it was a great success.

My sleep quality last week hit a HIV record, so I've been working on my HRV for four years and it's really had a significant impact with other things, um, yeah. I mean, we've had the same conversation on the discussion board, how do we bring people together? You know, um, I haven't met anyone yet, whether that's the case. This group is a major concentration of people who know what they are doing. We're talking and then there's another side of the spectrum which is secular people. I haven't met anyone, well, 99 of the people know the Billboard team better than we do, and therefore the level of disagreement is so high, from every corner and level.

The level of trust that each person attributes to their own point of view is so high that it creates this situation where I don't see many productive conversations on forums because people just want to be heard and then everyone disagrees. Now I may be wrong. They may be different forms, but when I go out into the world and get involved, it's quite noisy in terms of people's opinions about what we should and shouldn't do and how we approach things, so I don't know. I don't know what the form response is and how we could do something productive maybe you do, yeah well I guess maybe the point is not an open forum for everyone, but you know there are other people posting material that is a subset of what you're doing or stuff like that and I feel like you know I suggested this on Twitter a while ago you know you and Lust Garden and um Chris Mirabelle from Lil Boos is doing something vaguely like this.

You know someone, maybe we should do it. Maybe you have the foresight to organize it, but maybe there should be at least something online where, you know, Oliver and others come together who have opinions but aren't like arguing against all of life. Yes, yes, that's a good idea, but thank you. thank you for everything you do, I think it's drawing attention, yes, and I would offer to know that I'm sorry for all the consternation that I call, because every one of you, I'm sure you know it, so I recognize it. Think on a broader level, people are just excited that someone is actually, you know, creating this more public outlet now for people together and they like to at least disagree with the data, so, um, yes, and by volunteering, it is a record that, as people.

I want to connect to get help coordinating something like this. I would certainly be interested in doing this and next we have Daniel, okay, Brian, yeah, thanks for being here. Daniel georgiev from um uh, so I founded a startup called sampling. human, we're vastly expanding single cell analysis beyond what it is now so that it can be used in things like Diagnostics, uh, yeah, and you just know looking at the blueprint it's incredibly hard work that's been done and it's incredible. It kind of makes me think of the gurus of Hindu culture, where you know they said they could live all these years, but it almost seems like to live all those years you have to have good self-control to be able to do it. you've earned you know your right to be able to do that so I so I I you know I uh uh uh yes I admire that um my I mean, I think when I do you know when I take various types of supplements or and I look After all these recommendations, I think that The first thing that comes to mind is whether I can really do something wrong with this in the long run and it seems like almost the process of finding what is right there should be a plugin.

Maybe I don't think that's the case, but you know, looking at it like there's no such thing as a free lunch and considering what I might be doing to myself in the long run, harm and can I predict if you know in advance that that's what I can be doing? So I was wondering how do you know because you're the first data point, how do you do that? What is your process when looking? Know? To answer that question, yes, it would be a bad question for my team. I mean, they think about this a lot, we get the same question all the time, so I would leave it up to them, but I agree, I agree with you conceptually that it's an important variable.

Considering that it's not variable is an important, methodical question to contemplate across the entirety of the program, it probably changes a lot as well, like where you are in your own aging journey, you know, yeah, I was convertible versus not you um. . Well, next up is Eric Foreign. Oh, thanks, okay, so my question is: Do you have baseline data for your bond workers that you're measuring somewhere like? It's not on your website. I was looking at that, but how do you do it? you know what normal looks like where is that data uh are you saying normal uh like what is it so when you say uh someone has a certain biological age there's like an amount of variation there's like a concern in that sense there's such a typical way of what I'm looking for is like scatterplots, like here's a biomarker that changes with age and has some kind of trend.

Do you have those scatterplots somewhere for the things you're measuring like the basics? Yeah, so Dr. Zolman built all that. Yeah, so this is it. This is primarily his brainchild of taking quantification of biological age on an organ-by-organ basis and he's worked on it over the last decade, so we have a yes, we have substantially more rigor than we've shared publicly, so I think for me, looking outwards, I think. People would think he looked pretty thin. We haven't shared it because you know, we didn't know what we're going to do with this effort, so we've shared enough to give people an idea of ​​what we are about. up to, but not behind the scenes, so at some point we need to consider how we do this because I understand that from a perspective like yours that's exactly the question I would ask very well and just to throw this out there so that this machine here measures skin autofluorescence.

The people who built it don't know this, but if you take a hot shower, it temporarily reduces your age by about 12 years for about half an hour. So that's the kind of thing. That variation is. How much of that is affecting what you guys have seen so far? You can not say. Yeah, I agree that that machine is here on my desk too, so yeah, so we use that too. What made that measurement change? have lotion on, yes, so yes, as we are, we are very aware that the protocols must beprecise, you need a certain number of measurements or certain durations of time, so yes, we employ that rigor in everything we do, well, thank you. very good and we have a minute to finish uh so unfortunately we don't have time to answer most of the questions but one question that I usually don't let guests live without is if the people here in this room and more they like it there later.

YouTube is enthusiastic about your work, which I think they clearly are, so what can they do specifically to help you in your endeavors that you work on and in some ways advance like some types of action items that people here could be taking? to support you um there's probably plenty there's probably a lot more area uh there's probably a lot of disagreement about what I'm doing and what you would change and what you want to see I think what we could come together on is moving the field forward in this uh of a data-first way and for other people to create protocols and share their data and methodical approaches.

I hope he comes in peace. I hope we can push this field forward. You know what I took. There's been a lot of people and there's probably a good opportunity to join forces a little bit here and push the field forward in a positive way. Wonderful, well I can't express how excited some of the divers are. that you came and talked about this, and you know how much we already salute you and welcome you, like the incredible effort on an individual level and, as you know, a really broad team at this point, to push this fight forward.

It was really wonderful to have you discuss the top layer of that Iceberg with us and I'll be sharing the links as well that Arcade put here in the chat with the group and then on YouTube. Thank you very much for joining. I don't think I hope it's not the last time we have you on um and we'll share. links to your various efforts as well and yes, can I just reiterate that if it ever proves useful and that I coordinate a smaller type of forum or discussion or something about this, very, very happy to do so, but for now, thanks for the opportunity of your work thank you all for joining and uh yeah I can't wait to see you guys on the next one see you thank you all bye.