Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19

welcome to another MedCram COVID-19

update

, we can see that we are at almost 400,000 total confirmed worldwide. If we look here at the new daily deaths in the United States, we can see that they are increasing. There have been some interesting quotes in the news here. for March 24 and they anticipate that the maximum number of cases is still two or three weeks away. In New York, the governor of New York has said they need 37,000 ventilators right now and they need to get another 30,000 because they have about seven thousand now, at this point there's an ominous warning coming out of New York saying that's because first what's happening could be what's happening in your community in about four to six weeks.

They are also saying that hundreds of thousands of people have probably already had Kovat 19 I didn't know they had it and recovered and they echo what we said here before, which is that you should check for antibodies because if they are positive, then they don't need stay at home. They could go to work, which brings me to this news story that was on Yahoo. The fever map could show how crucial it is to stay home to stop the spread of Kovat 19. This is a smart thermometer made by Kinsa that can upload the data of people who are taking their temperatures and putting them on a map and What they have shown here through this article, we will put a link to it, is that in Florida there are a number of people who have had elevated temperatures more than they would have imagined.

This time of year, if you look at the data, the blue is what you would expect and you can see here as you go from February 14th to May 14th, the percentage of illnesses should decrease as we come out of flu season and that is the typical range that we see and we can see here what is observed in yellow and then when we reach a certain amount outside of that range, that shows an atypical disease pattern and of course this does not require any testing, there is no data serological as soon as temperatures are taken. this is loaded into the database and during this point isolation measures were implemented and we can see an immediate drop, an interesting way to check if there is a public policy response.

The article goes on to quote mr. sang the CEO of kinsa in the example above Singh says the rise in fever coincides with reports of Miami residents and tourists ignoring guidelines on recommended distancing, the sharp drop, however, comes after they were adopted more extreme measures, including beach closures and other isolation tactics. In the area, Singh says they regularly see that areas where residents ignore social distancing are experiencing spikes and that as soon as they are implemented through lockdowns and other measures within five days of those aggressive actions, they begin to see downward falls. the curve and it is interesting to note that we know from other data that five days is approximately the average incubation period for SARS Cove;

They are not actually testing for Cova 19 with temperature, but as noted, fever is a key and early symptom of Kovat 19, so keep in mind I wanted to take this from a bird's eye view and if this represents the total population, So obviously not the entire population is going to be infected. There is some debate about exactly what percentage of the population will be infected. infected with Cove in 19, let's say it represents it so it will be called infection and there are a number of problems that could cause this ratio to increase or decrease and we know some of the things that they are employing at the moment to allow that. to reduce social distancing or isolation or even some medications that would be called prophylaxis, prophylaxis is a medication that would

prevent

infection, we don't have anything that's approved by the FDA, but that's where I would go right now, so what are the things that could cause the number of people with infection to increase, that would be apathy or just carelessness, we are trying to do social distancing isolation to reduce the number of people in the population that could get the infection and that is important because what we have here if We can imagine that these bars are on wheels.

We're trying to get these car trains through a tunnel that has capacity for the health system and there are certain things that will increase the capacity of the health system and there are certain things that will decrease the capacity and we'll get to that, but there's another intermediate step that really hasn't been looked at that seriously and it's this car here, we don't know exactly how tall they are, they're not drawn. to scale, but these are the people here from the infection who will go to the hospital, they will enter through the tunnel, hopefully they will be shorter than the tunnel, otherwise there will be a problem, so what are the things that are going to increase ? the height of the tunnel that will allow the personal protective equipment of health workers to enter, which will allow the capacity to be greater because they can do more, have ventilators that would increase the capacity of the health system, medications, not just clinical trials to see. what medications are appropriate, but also the manufacturer and delivery of those medications will also be key, what would decrease if healthcare workers had to be quarantined because they did not have personal protective equipment or if there is no PPE. either because people are taking the masks or there are simply not enough masks for healthcare workers to use, so we are seeing a lot of resources being spent right now for the development of manufacturing personal protective equipment that we are getting. the government involved in trying to convince manufacturers to make more ventilators, the FDA is waiting for these clinical trials to be completed so they can decide whether or not to indicate those drugs for use in kovat 19, but of course we have other medications that have not been labeled for use in kovat 19 and we are using them as unapproved at this time because there are no FDA approved medications for kovat 19 and we are starting to get manufacturers to make a lot more medications so We have focused a lot of energy on trying to increase the size of this tunnel because we know that there are a lot of people coming down the road, there will be a good number of people going through it and it turns out that we know that about 20% of the people who get infected will end up needing to go to the hospital to be hospitalized.

About 80% of them will simply have a mild case, so 80% will not have hospitalization. What's going on here? Well, we're putting in a lot of time and effort. towards social distancing isolation and things of that nature, so up to this point is where we have seen most of the effort being made to handle this situation with Kovan 19 and the question remains what else can we do and I suggest that we where we should also focus is on this middle section because the question really comes down to why 80% of an infection does not need to go to the hospital and the answer is very simple, the answer is your immune system and the reason we know that That is the case is because older people have more comorbidities, they generally have weaker immune systems, younger people generally have stronger immune systems and that is exactly what we are seeing in this situation, older people tend to be the ones to have than going to the hospital, that's not a big surprise, there are exceptions of course, at all levels, there are young people who end up going to the hospital and there are older people who get sick but then recover on their own, but in general 20 % who end up in the hospital have a lower immune system overall and in fact the way this box goes up is if you have a bad immune system and the way this goes down is if you have a good immune system and Until the At the moment not many resources have been invested to ensure that we have a good immune system and I think this is a good area to consider because if you had a good immune system here to

prevent

you from going to the hospital, a good immune system here can also work could have prevented you from getting the disease in the first place, so I think having a good immune system is of utmost importance and there are two reasons why that is the case, because for you personally, if you can improve your immune system then You won't go to the hospital, but even more importantly if you don't go to the hospital, that means the hospital doesn't need to deal with you and can focus its efforts on someone else.

Now let's notice that we "We are dealing with a differential of about 80 and 20 percent, which means that if we can improve the immune system by a small amount, in other words, if we can improve the immune system instead of 80 percent percent, go to 85 percent so that 85 percent don't do it. No need to go to the hospital, that means this 20 percent drops to 15 percent, which is actually a 25 percent drop in hospital admissions, which would have a massive impact at the hospital level and of course , we all hope that if we can reduce this, then we can finally slide this car straight into the tunnel without problems, hopefully, all these things work together social distancing isolation a good immune system medications delivered when they need to be personal protective equipment ventilators clinical trials that produce good medicines all these things can work together so that when we reach the peak we can take care of all the patients that we need to take care of.

There are two components to your immune system. There's something called innate and specific, the innate part of your immune system. It is made up of components of white blood cells, which are the soldiers of your military immune system, which basically indiscriminately take in anything foreign and destroy them. You do not need to have specific knowledge of specific antigens, which is why it is known as innate, while the specific. It must be taught and shown specifically what the foreign antigen is so that it can produce antibodies against that specific foreign antigen, so if you have a pathogen here, when the pathogen arrives, it must first penetrate through the innate immune system.

What are the components of? In the innate system you have things called natural killer cells, you have macrophages, these are cells that devour the foreign substance, chew it up and take little pieces of it and then present it to the specific portion of the immune system so they can see what parts of it . looks like and then make sure they can identify it later, also neutrophils are part of that innate system and generally what happens is you have a pathogen that gets eaten by the natural killer cells, the macrophages, the neutrophils, the macrophages Generally, they take pieces of it. and present it to the specific arm which is called an antigen presenting cell which is a macrophage and there are two types of cells here there are T cells and B cells and generally T cells are the things that are involved with the cell. mediated

immunity

where there are cells that are problematic and these T cells can kill them, there are T4

help

er cells that can also

help

communicate, B cells on the other hand secrete antibodies that neutralize the antigens.

Keep in mind what is happening around the world there is something called the B C G

vaccine

. Now the BCG

vaccine

is administered in various parts of the world. It is an injection given to young children to protect them from tuberculosis, although it is not tuberculosis. There is a crossover between the vaccine and the innate immune system response. to tuberculosis, the reason they are doing this in different parts of the world is because they have noticed that when they give the BCG vaccine to young individuals, these young people not only have a natural killer cell neutrophil macrophage response or the innate response as well They have a specific response against it that is useful in trying to kill tuberculosis, but they have also noticed something else: it seems as if the specific arm of the immune system is talking to the innate after it is accelerated by vaccination and is using a carrier called il-1 beta now when this happens it not only accelerates the specific but it also accelerates the innate to the point where when they give the BCG vaccine they are seeing a 30% reduction in viral infections.

There was some criticism of this study, but in 2016 there was a review published in the British Medical Journal that showed that there was an excessive reduction in mortality after the administration of the BCG vaccine that could not be explained by tuberculosis prevention alone. So, more studies since 2016 had confirmed that this is what is happening. In fact, it culminated in a study where they administered the BCG vaccine and noted that it protected against a completely different pathogen, the yellow fever virus, in a weakened form. Also seen as a vaccine, something new and interesting was that when the specific arm of the immune system was stimulated, the innate arm was also stimulated and therefore, if the immune system could be accelerated by giving aspecific antigen that may not even have been related. to what you're trying to protect against that a boosted innate immune system could protect against another virus and that's exactly what they're hoping to do here with kovat 19 and that's why there are a number of studies around the world including Greece in The Netherlands , Australia and the United Kingdom are considering giving the BCG vaccine to the elderly population and high-risk people such as doctors, nurses, healthcare workers, etc., and if they can give the BCG vaccine to them, they hope that innate

immunity

increase enough. so that they do not contract the infection.

I'll put a link in the description below to the art of knocking that describes this century-old technique. The tuberculosis vaccine robs the immune system against the new

coronavirus

, but you can see here in this graph that we are looking at the areas in red As we mentioned, the other area we should look at is the areas in green, even if it helps a little. Many of the problems we have here in red are the system trying to get PPE to enough hospitals so they can use it. We are having a shortage of our medications, trying to get enough of these things to the hospital.

We will ask a different question: what are some of the things we can do without having to worry about a healthcare delivery system that can improve our immune system, so for future

update

s we will take a look at the data of things that can improve. your immune system is fine, thank you for joining us and don't forget to watch all our med creme videos on our website Med cram comm, see you next time.