The Aging Process Is UNSTOPPABLE. Or Is It?? Anti-Aging Secrets w/ David Sinclair

my diet has deteriorated since I started, not something I'm proud to admit on the show, but I'm a pretty pretty, you know, focused on what I eat and what I put in my body guy and I've gone through a bit of a window. here in the last three or four months where I just wasn't as diligent or vigilant about it and I haven't gained weight and I don't know if any of that is connected to the two, but it's certainly something that I've experienced since I've been doing it, uh yeah, and then how much time do you spend in the light?

The cycles are usually 15 to 20 minutes and I like, I try to do it twice a day. Oh, and my bed has different configurations. You know, one is for immunity, another may be for energy and things like that, and I just know it's one of those things. What are you doing, are you like I am, am I wasting my time here or is there some benefit to it, so I'm glad to know that at least the studies say yes, okay, okay. Let's talk about other things that we can do that are beneficial, so we'll get to practical things that people can do.

The first thing is we talked about this the last time you were here, but you know telomeres have been one of the newest things. age or they were ways of measuring

aging

and you kind of told me no, it's not like that, how did you say my real age is less than or your real age is less than your real age? How are you measuring that? How is age measured? Now, well, in a couple of ways, okay, I've been working with a company and in outreach, I was, I'm an advisor to them, an internal tracker, they came out of MIT, I saw them about 12 years ago, I joined to its board of directors, no.

It no longer exists, but I have nurtured this company because I truly believe in it. What they do is a blood test that you can do at your local Lab Core's request or even ask someone to come to your kitchen, which is what I do and do. you know, every three to six months and it's a dashboard of my body and then those 40 measurements of things that I mentioned like hba1c, there are other things like CRP for inflammation, okay, of course, blood glucose levels, there are levels of vitamin testosterone, it's a compendium that goes into an algorithm that's based on how these things change over time with age for your gender and um, I guess you're your race and other things and then it's calculated again to say it's well, compared to other humans on the planet, are you older? or younger than them, the average man, so I can trace.

I have mapped myself for all of these parameters individually and as a compendium as an algorithm for a score called internal age score 2.0. Where do I sit compared to other 52 year olds who are white? Caucasian, so young, yeah, uh, and I'm at the top, you know, no, I'm better in terms of that number of uh than 98 people my age and that two percent bothers me. I am very competitive. and I'm working to increase it. I want to be. I think there are one or two people out of thousands who are better than me, but I stopped taking statins just to check it out because I was losing my memory, but yeah. now i'm on a statin it's ok but i quit it and my cholesterol shot up so your cholesterol went up so i mean i need a statin it's in my jeans my dad my grandma took it i'm on it too one, oh you.

Yes, okay, yes, yes. I mean, I wouldn't say that if you don't have a problem and you can't, if you can control it with a diet, do it because there are effects on the brain and one of them is memory. yeah, yeah, one of the other things too is that your cholesterol can get too low, your LDL can get too low and that's not healthy for your brain either, right, that's actually true, yeah, and yeah, I'm just saying I'm among the first two. percent or one percent, true, true, but anyway, people are going to think that I'm a little, too competitive, but I have plotted my blood biochemistry over the years compared to the average human and optimized each "An experiment is long-term, it cannot be done overnight, but I think that is what modern medicine should be, that we constantly monitor ourselves and that we do not go to the doctor once a day year for a check-up to tell you how you feel. you're sleeping you feel good, go home, that's not medicine, yes, that's therapy, yes, my medicine is and the future of medicine, and for some people who don't want to invest in this and spend their time and money , you can get devices to read your body continuously we have talked about continuous glucose monitors on our arm but there are rings, okay, I have this ring too, I just won't use it today.

I have the water ring yeah there's even a bio button um I brought one today in case this came up. I'm holding a little gray square device that's maybe a quarter of an inch thick that I usually stick to my chest and it measures my heart, my vibrations, my movement and This thing can tell you if you're going to have a heart attack next week, something important, yes, but other things it can even tell you if you have a cold or flu or if you need antibiotics. or not and this is the future. I raise this as an example of what medicine should be like, that is, being checked not once a year but a thousand times a second, and when that is ubiquitous, then the old way of doing medicine will be.

It's going to look medieval, it's very right and you know guys, I'm lucky enough to have that too and it's like, you know why they want things to be controlled? Because the truth is that most cancers are detected early or are very treatable, it is detecting them late. a heart disease problem caught early can be treated like we've talked about with, you know, statins or something like that. I'm not making any medical recommendations nor am I a doctor, I'm not even close to that and that's why I want to ask you some medical things now because I know you don't feel good about a couple of things that I do and I want to ask you why so let's talk of the things we can do.

A minute ago you talked about hormones. levels and so I have been and I know what you are going to say, but I want you to explain your point of view on this to the audience with complete transparency, the audience knows. I have been taking testosterone, some form of testosterone replacement therapy. My God, it will be 10 or 15 years and I know that testosterone, at least in my case, is negative, we are going into a lot of detail here, but it can negatively affect HDL, for example, it can suppress HDL, which mine is already genetically enough low, so there is A danger is that HDL is the good cholesterol.

I know that's a negative for me taking testosterone. That being said, I look at friends of mine that I know who are in their 70s and have been men who have been on testosterone therapy for say 20 years. Compare that visually to someone like my dad who passed away last year and visually externally these guys that were on testosterone look 20 years younger than my dad so I'm not arguing this with you I want to understand that's why the first one What I asked you today is if visually you look younger, are you probably younger internally? Because visually, if you take someone like a well-known actor that most people know that he's been open about taking testosterone, that he's a high-earning friend of mine. from boxing movies and stuff so you compare him to my dad who is about the same age and visually they really looked like different species almost at that age so what do you think about hormone replacement and if you're not in favor of which ?

I think you're probably not specifically for that, well, I'm all for keeping your hormones at young levels. Okay, I'm all for keeping your body the way it was when you were 20. And however you can do it and it's safe, do it. Well then I agree with hormone replacement therapy for women and men if necessary. That's fine, but you think maybe it's not necessary. I am interrupting you. Well, that's the point where I've done my best to find ways to in myself, so you're dirty too, you're in that 300 to 700 testosterone range in your body, you're saying right now, your levels Hormonals are that normal at 50, without any um, I'm actually naturally taller.

That averages 20 years and naturally that means I've worked at it. I have changed things, it is good in my diet. I've done things and they disappeared. What are some of those things? Well, exercise helped me develop. I'm not as bulky as you, that's for sure, but from my basal state, which was pretty negligible to have any muscle, my quads, mainly big muscles, back muscles, plus deadlifting, this kind of stuff. , that helped me a lot and I improved it. it was around 500, okay, it's almost doubled in the last few years with changes in my diet, changes with supplements, but I didn't really do it.

I can't tell you scientifically which of them has contributed, but it's been steadily increasing, which is good, if it had crashed I would have stopped taking below or close to a thousand now, that's incredible, it's shocking, actually. because I haven't done anything obvious, you know, you read online what increases testosterone. I'm not doing a lot of that stuff, so I guess I'm lucky because there was some good genetics that was handed out to you. Compared to some of the other things that weren't as favorable, that's because it's incredibly high for a 52-year-old, yeah, well, you know, I want to be useful practically, so some of the things I do are so this fast has helped me, I think. that when I started well I don't call it eating pheasant once a day, I made you call it fasting, yeah, okay, people know what that is, um om a t a d, uh, the other way to do it, uh, call it a meal at day. but that seemed to help and so I also had to give up a lot of fat and a lot of meat.

That's not going to sound good to everyone. I know, I don't want you to know, yeah, but I think that helped me and I lost. weight and that may have contributed to doing well. I mentioned how much weight I've lost, but here's what I don't think is bad at all to supplement. I'm not against. I think what you are doing is perfect. acceptable, but I heard you say something about burning the candle at both ends, what did you mean by that? Yes, then it is an abundant sign. Testosterone is fine, yes times are good for building muscle, but then I have to look at the clinical data. it will not extend your life expectancy and that is very clear, there have probably been 50 million dollars worth of clinical trials done that say testosterone will not make you live longer, it will help you get more muscle which will keep you from falling off and break your bones, which is a problem for most older people, so that's good, but there aren't many downsides either.

I've seen very few, if any, no more cancer, it's not right, no, so put it this way, it won't hurt you. If you feel better and you're stronger and you look better, you know it by all means and that's why doctors prescribe it. Otherwise, you know there would be a warning, but will it make you live longer? Not seem. Unfortunately, I like it, but I think one of the challenges is that for most people you know that if one thing is good, many are better and what I find with people who start taking hormones is that you need to do it.

I think it can become a form of addiction and you say, well, I'm at 800, I look like this, let me take this to 1500 and see what I really look like and then there are some things that are unhealthy, your hemoglobin levels, things. so I've already mentioned that there are things that can get out of control and if you don't, you know you're very careful with them, so those are some of the things that I just want to ask you because it's been very common for women to become You also know some form of hormone replacement and in my own case, I'm on my last labs.

I've only been on 400 with supplements and one of the negatives, I think certainly for me, is that my own body has probably produced a decision where it no longer needs to be worked on or produced because I have these exogenous things that I keep putting in. my body, so I know that once I've made that commitment, I'm committed for life. So there are some that I'm not a fan of or I wouldn't necessarily recommend starting until you have to until those levels are lower and here I'm telling you what I propose, which is a really fascinating part. from the interview, so we have that, how about, any of the peptides, so I'm curious about growth hormone, yes, or no, no, no, why?

Well, because there is a lot of evidence, both in humans and mice, that when you have low amounts of growth hormone you will live longer and be well again it is this abundance in the face of adversity you will feel better with growth hormone you will be cured better, but in the long term all the evidence points to the opposite, that having low levels of these growth signals is better for you, in terms of tumors, also this motor pathway, part of the other part, is its impact on tumors . Is there any relationship between those two things with tumors and does growth hormone affect the size of tumors? everything in your body to grow, for example,Potentially, I mean potentially, but fortunately there isn't much evidence that growth hormone causes cancer.

Well, then I would say it could potentially cause a cancer in your body to grow well if you. I have one, yeah, yeah, I mean part of the downside of all these treatments is that everything is fine until you have a tumor and then, then, you might actually help the tumor. Do you feel that way about testosterone or are you saying that? about growth hormone or both uh growth hormone plus testosterone I think that's okay, okay, I know this is something you don't normally get asked, that's what I wanted to go there, right, yeah, and then the other thing that took.

I think it keeps my I think at least let's say the evidence points to sometimes I have to talk like I have a teacher, is that by activating these other enzymes that are the second component of those three, this kind of two that I work with . You can activate them by doing the kinds of things I do in my life, but I can also take a supplement that increases NAD Capital and there are people who take intravenous NAD supplements. It's something important, it was discovered in my laboratory. partly, what about 2002, when I was a kid? But now it's a big deal and the reason NAD is popular is that it activates these sirtuins and we have seven of them in the body that we talked about last time.

The seven are the protectors of the body. There are three that protect the DNA and the clock slows down. down uh we think and then some of them are in the mitochondria there are three there and then there is one that floats in the middle in the water that is between all that and that is number two now I have 32 it controls the production of hormones uh and if If you give it to the cells, they will make more androgens and one possibility is that the reason my testosterone is working pretty well is that I have super high levels of NAD because I've been supplementing for about seven years with n m n, which is a precursor to NAD, stay there, okay, I want to go there, so next on my list was NAD, so of the people I know who look strangely and unusually young for their age and that I have met in the last 36 months, no I can overcome it.

How many of them have told me that I'm on NAD and metformin and I'm talking about everywhere from a gym to a golf course to a business meeting and I'm talking about visually striking young people, mainly people? in their 50s which to me looks like 30-40 years old, so when you say NAD, do you believe in IV therapy? Do you believe in things that can be injected subcutaneously or are you talking specifically about this precursor? that you were referencing well what I think, it doesn't matter that much, but the scientific evidence points to taking a supplement every day, one gram of nmn, which is this precursor, means nicotinamide mononucleotide for the amateurs, I'm just swallowing one from those. uh or a thousand milligrams is enough to double your NAD levels in your bloodstream um and triple it if you take two grams now I'm 52 so if I were an average human I would have half the levels of this NAD molecule as a 20 year old. , so doubling it is my goal, so I've been taking a gram of nmn and swallowing it every day or you know, the last one, whatever it is, it's not used for at least seven years.

The question is what about NAD IVs? There is very little data on that. Yes, I would say I have tried it. I found that it felt good. Especially later, during the

process

. Have you tried it? I have a little cramp in my stomach. Yes, yes, I found it with the IV and I also took Sub-Q and I have a really uncomfortable burning sensation in my stomach. It's ironic that you say it's exactly my experience, so there is some evidence that it's good for uh, treating addiction, but there's really no solid scientific evidence that it helps in other ways yet, but that doesn't mean it doesn't help, it just means it hasn't been studied enough, doctors haven't done enough placebo controls and it's hard to give people a placebo, especially if they're paying for it, yeah right, so I'd say the jury is still out , but I think the science is there and it should activate the sirtuins and put them into action and at least for those few hours that you are receiving it and it will probably increase double and triple the levels in your bloodstream.

It will help you, but I don't know in the long term. I'm so fascinated by this stuff, as everyone can see, so you're getting stuff here. you don't find most other places, so, these are just things to think about, these are not necessarily recommendations, things about things to think about, then there's metformin and, um, so, you know, I gotta tell you. this to you and me. I knew that this is one of my passions. I haven't had a great genetic hand either. By the way, guys, there are all kinds of things that we could talk about genetics today that you can study right now to see if you're predisposed to heart disease or different diseases.

Cancers you can even find out if they come from your mother's or your father's side. There are all kinds of things you could discover right now. My genetic hand is shit. It's just mom and dad's side and neither of them are good, and both cancer and heart disease, when? I originally met David, this conversation really mattered to me and I started taking metformin. It's just me personally. I'm telling everyone about my own medical stuff. I started on the NAD precursor and tried the IV route. things and I myself tried Sub-Q, so metformin helps with glucose in the body in some way, glucose metabolism is correct, so why do you think metformin works and you feel really strong like you do? did you last time? you heard it, yes, I feel even stronger, there is a lot of data from looking at tens of thousands of people who took metformin and people who take metformin and who have type 2 diabetes and who would normally live a short life because they have more cardiovascular disease. are

aging

faster, they are actually relatively protected against these diseases and type 2 diabetics who take metformin live longer than people who don't have type 2 diabetes, that's a remarkable observation and because once you start studying dozens of thousands of people begins to seem real, especially for those people who are predisposed like you to cardiovascular diseases and other problems such as cancer.

It's very clear that metformin on average protects you against those diseases because it doesn't just work to keep glucose levels low, remember it's activating mitochondesis and protecting the body through these defense mechanisms now people might be thinking: well , you have these protective mechanisms, but what are they really doing to make you healthier? Well, I've only mentioned one of the things they do, which is they flip over those old proteins that are oxidized or have glucose stuck to them, but they do other things, they protect telomeres when you turn them on, but they do something else that's really interesting, and is that they can rejuvenate stem cells, etc. you get protected stem cells and then they can divide and then they can repopulate the body.

Another thing they do very well, particularly sirtuins, is that they help repair broken DNA. Anyone who has been under the sun. I was Australian. They have seriously damaged me. the Sun aging you, it actually is, we know that DNA damage accelerates aging in my lab, we can age a mouse 50 years by doing this

process

, the Saturns will slow it down. We had a scientific paper in 2010 2018 that showed that by increasing NAD levels by giving mice and a man the same molecule that I take, their DNA repair systems were much more efficient and if you damage them with radiation, which we were trying to simulate space radiation, but it's also similar to cosmic rays that you get if you fly a lot, which I know you do, and a guy was protecting those mice from harm and you can see the damage that you look at in their livers.

There was damage, damage, damage to a normal mouse and give the men the repair and it wasn't there. For the most part, that's another way you can protect against aging. This is so good, very good. Let's keep going because I love it. Any disclaimers on everything we've said so far what would you say to someone who says I have to take metformin or NAD is there a disclaimer? some inconvenience? Something I would recommend you do just to make sure everyone has heard the entirety of your thoughts on this. Yeah, well, a disclaimer is that I'm not actually a trained doctor. a trained doctor, but I'm not a trained doctor, I'm a PhD who studies molecules, um, and that's like that, whenever you want to change something in your body, even if it's a diet, but if it's a supplement, um and, of course, a medicine.

I need your doctor, uh, you want to consult him, so your doctor needs to know everything that's going on in your body because supplements are sometimes as powerful as medications, okay, and if you can't get them, for example, this is a Good point that I think you should mention. If you can't convince your doctor to take metformin, yes, there is an alternative and you know what I'm going to say, it's a plant molecule called berberine from the Berber plant and if you're in clinical trials, if you take it at 2 grams a day, yes. Reduce blood glucose in a similar way to metformin and which you can buy at any pharmacy or online.

That's where I started after our interview. I went to my doctor and told her we were on metformin and she said no, no. at this point not yet and um and that's where I started and then after a period of time she did some more research and agreed, if you've read anything about Mott's C, I've done more than read, okay? you already know about mot C, let's see well, I know the scientists involved and I helped them start a company. Come on, alright, I'm a little embedded in this field, I know, but this is it. I'm older than you think. so much C is really interesting, I really like it, okay, I liked it so much that I started a company, yeah, so motzi is a super interesting molecule from an academic point of view, okay, and from a physiological point of view, okay , motsi is not made by DNA. uh, from the DNA in the nucleus, which is most of our chromosomes, it's from the chromosome that's in the mitochondria, it's the mitochondria because they're like these bacteria.

They had their own circular DNA, it's not a chromosome, it's circular and it's embedded in that circular piece of DNA. In the mitochondria there is a little gene called Motz c m capital mot C and the mitochondria make this little peptide into a little piece of a protein. The peptide is just a small protein that leaks into the bloodstream and tells the rest of the body that a certain part of the body is experiencing hormesis, so when you exercise your body secretes mot C into the body and mozzi is very small, you can synthesize it and you can even obtain it.

I don't know if it's still available in the US, but it is. in clinical trials right now at this company it's called Cobar cohbar, okay, and it looks promising as a treatment for fatty liver, but I'm hoping that other age-related diseases maybe even removing plaque and things like that, and there's all kinds of fascinating stuff, so I'm really glad we had the opportunity to talk about all of this stuff today, okay, some practical stuff just for a second or interesting stuff, um crispr, we've talked a little bit about crispr, but this concept? where can we allow ourselves to really alter?

DNA like I had some friends of mine who knew I was going to talk to you today and they were like, please get the update so everyone tells everyone here what specifically crispr is, but where are we? Right now, where are we? If you were to forecast, say, within the next five years, where do you think we won't be able to alter DNA in that way? Yeah, well, right now it's possible to add genes to the humans we've cured, not knit them. and doctors have cured incredible genetic diseases, blind people are seeing again, yes, but it is few, there are thousands of people, it is not millions yet, but we are getting better at it and, eventually, probably in this decade, we will see able-bodied people. of adding genes to their bodies more frequently, but crispr is different crispr is not adding genes, it is actually changing your genetic makeup permanently, and where we are is that there are some genes or some studies that have shown that it works in humans that can be correct. sickle cell anemia and fixing that is a little bit easier because it's in the bloodstream.

Trying to fix Alzheimer's with crispr is going to be much more challenging, the blood is easily accessible and the way we do it is by putting in a crispr system which is an enzyme that you can direct to change the DNA with a barcode, so Our DNA has different letters, there are six feet of this DNA molecule in every cell and there are these four letters acting and they are in a different sequence and what makes crispr. that's something incredible if you think about it is that you can give it a code that says go find the sequence that is t g c a g c and you will find it in billions ofcombinations in those six feet and come in and just change that's wrong. a barcode and uh so I would say in the next five years it will be quite common to fix genetic diseases with crispr and from time to time things get really interesting when we start fixing things that are not genetic, maybe we all want to do it . fix our predisposition to diabetes, we could potentially go in and fix that before we actually get that disease and compensate for not having great genetic bloodlines.

If you put a time horizon on that, would you think something like that would probably be it? For healthy people it will take longer, right, doctors would rather do no harm than do good, and it is probably 15 years away from becoming commonplace, there are other technologies, one called SI RNA, which is similar, but in reality stops production. of protein instead of changing the genes, it is a step down and that is being demonstrated and there is a drug on the market to treat high cholesterol and there is even a drug for fatty liver and more and more we can change the genetic code or the codes that come from the genetic code, which is RNA, which we've all heard about because of the backdoor law, but yeah, well, it's amazing that we can now read DNA and rewrite it, and at my work we just discovered that recently.

Discover how to activate three embryonic genes in the body. Well, and when we do, it's just the three right genes that reset the age of the tissue and rejuvenate it. Are you kidding? This is the work you are doing right now. So also, I'm processing all of this, like I think when we first talked about this, I was like, yeah, it's going to be there, like adding jeans, they'll do a little bit of that, but they actually like to alter the genetics. sequence of someone who will not be in my lifetime and you are saying that you think that somehow that will be in the next five years, we will be doing well, there are patients who have already had it done, but to make it a general story, yes, five. to fifteen, depending on the disease, the more severe the disease, the faster the FDA acts, what are the things you're most excited about right now, like in your job, what is it, these are the things I'm most excited about right now, that's easy, cara By the way, it also changed when I ask you, it's easy, yes, so we published a year ago on the cover of Nature magazine, which is the highlight of any scientist's career, that we could reset the age From a complex fabric, we choose the mouse eye.

We let the mice age and go blind and we reprogrammed their eyes using these three genes that are called OS and K for short, yeah, and we turned back the age of 80 and they could see again, so what we're talking about is Having discovered that there is a reset switch in the body to become young again and the information in the body to be young is still there, so in theory you could take someone who is 100 years old, oh my god, and reset their body to be young again, now it's exciting. The thing is, we've been doing clinical trials or preclinical trials and there's no apparent downside to this yet, it's not that great, that's amazing, yeah, so I went home that day and said, hey, we've cured blindness and my family went. yes, can you just unpack the dishwasher?

That was a sad day and that's when I knew I would never be able to impress my family, but we've been working ever since, so we first made this discovery about three years ago and it ended up appearing in my book a little bit. It was exciting to make this discovery, but since then we've been working hard to find out if it's safe enough to introduce into humans and now we're testing it in non-human primates just to see if it's safe, gosh, and if everything goes well in the next two years, hopefully we will cure blindness in people, that's absolutely amazing, there is absolutely banana, but it gets better, okay, the eye was something we chose, I didn't think I would do it. it works better on the eye, in fact I thought it would probably work worse, but we found out that there is a universal reset switch so you can reset different parts of the body, you can reset the skin, which one you can reset the muscles, uh, you can reset what.

You did it? Yes, the skin was easy, so we use the same genes, so we are basically activating an embryonic program in elderly or middle-aged people in their cells and in mice and they become young again. What does this mean? This means that one day it will be possible to reset the age of the body that we have made in mice now the question is how soon we will be able to introduce it into ourselves that's bananas is there here is the here is the guy he grew up with Let's skeptics all over the house assume that's true.

Did everyone just hear what he just said? By the way, it is possible that we can reset the age of a human being. We have already been able to do this now and other agencies. That's one minute. process that correctly and as I process it I say wow, that's exciting. I hope I live long enough to be able to reset my clock, that's the key, the things we talked about today, yeah, the exercise help, um, well, what? What's the other thing, hot and cold? These are designed and the supplements to keep us all alive until this technology is available because it's not just about slowing down aging, which we can do quite easily by just making these lifestyle changes, but restoring the age there is.

There's a UCLA study that shows it gets crazier. There is a study by Steve Horvath and Greg Fay that was published during the first months of the pandemic. They treated people for a year with a combination of metformin, a little bit of growth hormone and um. DHEA to offset some of the problems with growth hormone that can cause type 2 diabetes and they found that when they measured the body clock it went back about two years and at the time I thought yeah, okay, two years, that's not much, but then I started thinking that if you could do that every year, it would be pretty interesting.

You're literally aging backwards, and I don't know about immortality. I would just be happy with 10 extra years of happiness. healthy life or even two years, but we are now at a point where we can control aging quite easily in my laboratory, we can push aging back and forth in my whole, aging is a male evil now that we understand how It's controlled and what causes it and we even have a lot of brains in the lab, we can take human cells, so Ed, I can take your skin cells, I can turn them into stem cells that are pluripotent, which means I can do anything. from you if I wanted to and This is no joke.

I could make a sperm from your skin cells and an egg and fertilize it so you can clone me. Could. I could clone you. I won't do that because it's illegal, but biologically we could do it. My God! I'm going to get all kinds of phone calls, you're there, come on, clean me up, yeah, no, but what I am, the important thing is that I can make organs, lots of organs from you and test drugs, and I might know what we're doing. in the lab is that we have oh yeah, yeah, yeah, personalized medicine, yeah, wow, so when you come to my lab and you have to promise to come, I'll show you that we grow these mini brains in the lab and we get them from people. that they are predisposed to Alzheimer's or not and we have a way to age those brains so that they are now 80 years old even though they are only a few months old and they lose their ability to fire electricity and become demented on the plate little mini brains on Instagram.

I have shown some photos of these, they are very cute, so we give them Alzheimer's and dementia on the plate and then what we do is we have the system to activate those three embryonic genes OS and K and those brains regress in age, but this is the interesting thing: Alzheimer's disappears, the electrical activity returns now we do this in a mouse, we make the mouse age, we simply let them age or accelerate it and now we would be reversing the age. of those brains in the mice and you can guess what happens, they get their memory capacity to learn again.

Incredible, so you listen to what you say. Is incredible. This is my day job, so it doesn't seem that exciting, but it is when you talk about it, it's the most exciting thing, listen, we're in this moment where there's all this doom and gloom about you, you know our well-being, our health, the pandemic and all these other things, and it's something we need to be very aware of and pay close attention to. but right at the same time I feel like young Sergey and I were also talking about this. I know you know Sergey and you like Sergey too.

It's almost like you can find a way right now to stay healthy on this planet for everyone else. In the next 10 or 20 years, if you can achieve it, there could be an extension of your life by a magnitude of another potentially healthy 20 or 30 years, possibly, and you said 10 before, did you just find a way to extend your life to find the way is what we're describing the hot and the cold, the not eating as much, well, the look, really being sure of your glucose and how you process it in your body and taking a look at metformin and NAD and these other things , and yes you can really start putting those things together and exercising and eating healthy and getting on the right foot.

We may be living in a completely different world and in a matter of a decade, yes, exactly right and now because technology is already changing so fast. and it's just going to be exponential every year you stay alive you'll get another three months to live right now stay alive because eventually it's going to be for every year you stay alive you'll get another year and eventually you'll have negative birthdays come on dude, it's no. I used to say this was futuristic. Yes, you did it. That's why he has so much credibility with me. You used to say many years ago.

This is very far away. This is possible. So for it to be you. tell me no, here is the window that it is possible, probable or possible, it will have so much credibility that some of the best scientists are working with me on this, not only at Harvard but in companies that know how to make drugs, so this is No. just, oh, one day it will happen, there are investors, um, yeah, sure other investors have jumped on board, so Jeff Bezos and others have invested huge amounts of money, now there are billions to solve this, so even if it doesn't I achieve it.

You know, God willing, I don't have a heart attack, but if I do, you know the genie is out of the bottle, this is going to happen, it's just a matter of when, yeah, what does it mean to be, I'm just thinking about myself like you. We're talking about what it means to be a human being, which a decade from now will be a potentially very different experience than what it means and all the pain and suffering that so many people have gone through in their lives with cancers, heart disease and loss. of people. that they're still here for Alzheimer's and things like that to think about quality of life and people ask me all the time.

I was on a call before we did this with a training group that I have with all the things going on in the world. right now you know it and I and I told you I'm an optimist I'm an optimist about Humanity I'm an optimist about life I'm an optimist about our world and that's not Pollyanna I have reasons to believe it and you know you're my friend One of those reasons why The one thing I just learned from you and I'm so inspired by you is that there's something negative about people living a lot longer.

I think about things like food supply or things like that. Do you ever think about those things like we have to be very careful? here because you know there could be a problem that we haven't taken into account; In other words, other technologies must keep pace if humans are to live longer. Yes, the answer is yes and that is the topic of my next book. get out of this mess we're in living longer and alone from the mess that the world we've created is okay, I understand you, the stress and bad food around us living longer is part of the solution actually Well, by helping yourself you really help save the planet and that may sound counterintuitive, but let me explain to you first of all, there is an economic benefit to living longer, healthily, with adequate productivity, for sure , spending, the economy is driven by people who are healthy and dragged down by people who are not healthy, good point, yes, and we did the math, I mean a couple of brilliant economists in London.

I was just the third wheel, but they calculated that if lifespan could be extended by a year, let's say everyone was on metformin. Who could take it? So long-term savings in the U.S. would total $86 trillion to extend it to a decade. That's 365 billion T-dollars. This is more money than you can make doing anything you know. Save, stop all military spending, something we wouldn't do, but that amount of money can go to solving problems, like climate change, food supply. Sure, the other thing I do and I don't mention this oftenbecause it's common, you know. It's not the topic people want to hear about, but I also work on other problems on the planet.

I have a company that detects viruses and bacteria. It can diagnose anything from your blood. That's just one, but the one that's relevant and that you remind me of is, actually. I wrote some code, I wrote a pattern on the plane from here to California from Boston to preserve the fruit, so the same molecules and coatings in the fruit, while the same molecules that work in our bodies also work in the plants, so In fact, plants make most of these molecules that we ingest is one of the reasons why as stress, I stress plants because they make these molecules summarize.

I hope to extend the shelf life of fruits around the world and there are a lot of fruits and vegetables that are thrown away every day perishes yes you are extraordinary brother is there something that keeps you up at night and that you worry about ? I don't stay awake at night worrying. I stay up at night working and talking to people. I worry a little because I am not going to achieve my life's goal, which is to have a medicine that helps millions of people and that satisfies me. I don't care about awards and all that.

Don't you know I've won? a few and it doesn't do anything, you know, what I'm hoping for is a little bottle of some medicine, some medicine that will save millions of lives and then I'll do it, honestly I'll do it. Be happy and I'm guided by a mentor of mine, Philip Sharp, who is at MIT and actually literally won a Nobel Prize. Does he have his Nobel Prize on the wall? No, he has a little vial of the drug that he made and that's it. what he tells me is important to him hmm that's very good David okay a couple more things are there any other additional things?

I'm processing what we talked about today. I feel so good that you were here. I love you. I just want to say. This for you, I always learn when you're around me and I feel more optimistic with fact-based evidence of why I feel more optimistic and I'm grateful to be able to share today's conversation with millions of people listening to the show. There are some shows when I do them and I'm in the middle of doing them and I'm very grateful for this experience and now it's twice with you and I just want to acknowledge that there is something with you. another gift you would like to give to the audience hey, here's another supplement or tip or something that could extend the quality or length of life.

Is there anything we haven't covered that you would just add to what we've talked about? Is there anything related to mental health or something? Yeah, well there are a couple of things mental health is also very important to me. I have learned to reduce stress. Don't worry about the little things you think about. Will this be it? matter in five ten years I know that you are very, very good at this I would listen to you too I am also grateful thank you um and uh the ability to cope with pressure yes, um, I was a very nervous child and when I was 20 and 30 years old getting a job at Harvard was pretty scary.

When I was 40 and now I'm 50 I'm a relatively calm guy and you have to work at it, it's not a natural thing to breathe. More recently I'm trying meditation at night just for a while, about 15 minutes a day, but I'm finding I can even get by with less sleep. I have a helmet and headphones that help me. I'm not very good at meditation because my mind is everywhere, but it's called Brain Tap and I have no connection with them, but I like it. Brain Tap has headphones, you listen to relaxing music and a light shines in your eyes at frequencies that make you calm down, so mental health is very important because if you are always overly stressed, a little agitation is good, but if you have cortisol running through your veins, it will accelerate aging, okay, the other thing is that I am working to democratize another type of age test, which is your true biological age, which measures the chemicals in your DNA that actually biologically determine your age. and it starts at conception and continues even when you are young and can Basically, I take a blood test or a cheek swab from you or anyone and it predicts how old you are, but also when you might die if you don't change your life and do it.

What I want to do is give everyone the equivalent of their credit score and help. they improve your credit score, yeah right, so you have this number and this is what we think you should do given everything we know about you and in that way, empower millions of people to live longer, healthier lives. and we have a registry, so that's My gift, you can get it, so we are developing this test and it will be much cheaper than anything else. We just presented a pattern that reduces the cost by a couple of orders of magnitude. The website is called tallyhealth.com.

Get on that list and I'll get back to you and we'll see on telehealth.com and that's the latest result from my lab, but I think the same way medicine will help millions of people 10 years from now. be soon and that you know this training we do. I love touching people's lives now, not just saying oh, in five years, I'll get back to you, yeah, you're doing that, you did that today, um, here's one thing I just did. I would recommend to everyone. I would stay close to Dr. David Sinclair, so I would follow him on social media anywhere you can get it.

I'm just telling you that I think he's one of the most important humans on the Earth spinning right now. and I feel stronger today than before today and I have already told you that you know millions of people before today, so thank you for today. I enjoyed this immensely but I learned a lot and for those of you who By the way, you're hearing that where they should find you on your social media is the best place, yes, Instagram and Twitter. I am publishing data, there is not enough data available. I'm very science-based, but also by I've gotten a lot of feedback on my podcast that just launched and it's doing well, luckily it reaches a lot of people and we cover practical advice, not just science.

Some of the questions I asked you today were born from listening to your podcast. so I recommend it to everyone and guys, listen, I'm bringing you some of these people and it's free. All I ask you to do is share it because this is the fastest growing program on the planet for a reason and it's because of all of you. and it's because I'm lucky enough thanks to all of you to give you access to some of the most interesting, fascinating and inspiring people in the world who can teach you how to live better, longer, happier, more productive lives, and that's how we do it today .

David, thanks Ed, you're great, thanks for having me. I love you brother, it's okay guys, God bless you all, share the program as much as possible, take care of yourselves. Hey guys, thanks for staying. If you want to see more, click on the videos here. They are exactly what you need to see below and if you are new here, please subscribe and become part of the max out community and tell me what you think about the videos in the comments below. I read them all every week and select winners who get all kinds of prizes team coaching calls with me make a comment