Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials

Welcome to the new MedCram conference I am currently at a medical conference in Hawaii, but I will continue to make these

update

s. On the Worldometer website, you can see that they have divided the cases into active cases and inactive cases, and the numbers are still increasing, and these numbers may be underestimates. We will discuss it in detail later. Let's look at the graph of the total number of cases outside of China, which continues to grow and does not appear to be exponential. We take the logarithm, and we can see that it's not completely linear. When cases in mainland China are not included, the data is sporadic.

Some days they reach 79. The most recent day is 22 cases. Among these total deaths from the beginning of the year to mid-February, it is obvious Seeing that the disease is still developing, this virus has infected us humans as mammals, but do not forget that humans are a species that can think, act and fight to resist this virus. . That is what we are going to talk about today. Some people asked about the drugs that are being studied. Nature magazine published an article a few days ago that there are more than 80 ongoing

clinical

trials

studying new

treatment

s against the

coronavirus

.

The gist of the article is that with so many

trials

in China, all doing their best to find possible

treatment

s, there may be a lack of standardization in such cases. What is the standard and definition of recovery from illness? If there is no double blind, there will be intentional or unintentional work errors. We put the link to the article below. It describes the WHO's attempt to standardize these trials to ensure that they can be compared with each other. another to ensure authentic and reliable results, not just to promote new drugs. There are many drugs such as chloroquine phosphate, which have been shown to be effective in inhibiting the growth of the new

coronavirus

in vitro.

Another drug is currently being tested on 100 patients at ten hospitals. Another medicine is Favipiravir. The trial has 70 patients. Of course, there is also a drug Remdesivir, which is currently being tested in ten hospitals in Wuhan. This medicine was developed for Ebola Virus. It works in vitro, but it doesn't appear to work in vivo, but it remains a potential therapeutic drug against 2019-nCoV. Another concern is convalescent plasma, which is plasma collected from patients who have recovered from 2019-nCoV. antibodies against the virus, if donor plasma is injected into severely ill patients with COVID-19, it is expected that an immune response can be generated Controlled trials that worry me and many of my colleagues, if people are already talking about disease and it looks promising and it's getting better, can you guys make sure the research is accurate and reliable and the next thing I want to talk about is that's what I do?

I don't Epidemiologist, I'm not a hospital administrator, I don't work for WHO I'm just a pulmonary ICU doctor taking care of patients When patients arrive at the ICU, their whole system breaks down, I'm the one who puts the central venous and arterial catheters that we give to patients. Intubated, bronchoscopy, always interested in this virus, my job is to treat patients and I want to show you what I noticed in my clinic in southern California. In the last month, I have personally seen at least three or four cases of influenza A. These patients are not doing well.

Recently, a young man came to the doctor. From just reporting the flu to severe pneumonia, he progressed to requiring intubation in 2-3 days. He ended up on ECMO, which is cardiopulmonary bypass. The chart below is the CDC confirmed flu cases, most of them were H1N1 in 2009, which was a very bad year, and we noticed that heart function was affected in those patients as well. One of my own patients was seriously ill after intubation followed by cardiac arrest. The other had ST segment elevation due to viral myocarditis. Since 2009, the annual flu vaccine covers the H1N1 strain because I have seen such a large number of cases that it is not too late to call susceptible people to get vaccinated here.

Flu season is still a few weeks away. Remember to get vaccinated to prevent this deadly influenza A. If you are interested in our previous lectures, we have discussed sleep to strengthen the immune system, check out our previous lectures and website, there are many related lectures and information on various types of sleep. Conference on diseases Thanks for listening