Científicos de la Universidad de Chile crean medicamento para prevenir la metástasis del cáncer
Apr 30, 2023Actually, a group of s
cient
ists from the University of Chile created a drug that prevents cancer
metastasis
. This will allow the inhibition of the reappearance of tumors in the body. What is this product about? What scope can it have in cancer
treatment? one of the leaders of this research and a member of the Advanced Center for Chronic Diseases, Dr. Felipe Oyarzún, Dr. Welcome, thank you very much for being with us, thank you very much for de metrosur, well, one of these things and see what They are also producing in Chile and it really remains a lot of pride because it is also very useful for a disease that is unfortunate to say so, such as cancer.
You have somehow managed to stop meta
stasis
and the reappearance of tumors, how does this work, at what stage? Well, we have investigated a lot about this discovery. First, we worked with cell lines and we reached animal models, from there the cell lines. We investigated that the formulation was safe and effective and, sorry, in cell lines it was safe in healthy cells. effective in cells that were diseased and then we were also able to demonstrate that metastasis could be prevented in the laboratory after that we went to an animal model that is a very aggressive cancer model that is melanoma and where it occurs a lot and the mortality rate is very very very high and what we did was to see the therapeutic indication is it identifies you in the tumor, they remove it now and what normally happens is that after this process the reappearance of the tumor occurs in the place as metastasis in distant places and that metastasis is the one that ends up triggering death, we effectively after removing the tumor and immediately before closing the wound before putting the stitches we already put a dose of our formulation and a single dose was capable of completely preventing the reappearance of both phenomena while the animals that did not use it had a 70 percent reappearance and whose prognosis was rightly death I want to ask a very basic question because I want to imagine it you have given a dose what it means It is a kind of healing cream from the place where the tumor had been produced and therefore these tissues remain as in some way individuals to have again, it is metastatic, the cancer is a dose that does not settle, it is an injection dose that resolves what it whatever you want with the liquid water and liquidity before closing the wound it is as if the base instead of washing with water with serum washes with our liquids and closures with this liquid I understand that this has to do with a native plant that is turmeric now you develop something specific with turmeric which is this antidote this inhibitor let's say of future tumors it is not that you use turmeric as it is because there are people who have said they are not going to make me eat turmeric in the background and it is not that Of course, the procedure of the process that we developed could be scient
ific, like what happened with aspirin, before using the willow bark to relieve pain and then what was done was to extract it, remove it from the active acetylsalicylic acid and generate a medicine that medicine It has given you scientific and clinical certainty because you know the doses, you know how to administer it, it's the same thing we did, we are already working with the turmeric active ingredient called curcumin, which is known to have greater neoplastic and anti-inflammatory activity, among others, and we directly generate the medication with him with that asset already and that it has a whole development let's say scientific well I understood that this finally also had to do with a problem with the water something happened with the water that made this not work well that you do a whole process In order for this turmeric compound to work in the body effectively, it is a state-of-the-art technological process that it will contemplate and nanomedicine since it is what happens that this molecule is contained, imagine that it is contained as in a coin and that you and that you you swallow the coin and what is going to happen that you are going to find the coin in the bathroom later because nothing that was inside that could have had a benefit was going to be released we work with what we know is released and channeled it in such a way so that it is available and that it can effectively generate the clean effect and that it is finally transferred to the organism to the cell.
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cient ficos de la universidad de chile crean medicamento para prevenir la met stasis del c ncer...
In this case, we do the phenomenon topically because we apply it precisely in the place where the tumor is extracted and that is the place where it can reappear or metastasize to other tissues you were not talking about melanoma and this is a very aggressive type of skin cancer but one wonders if this also has applications for other types of cancers and it could be something like universal for all types of cancer or only for some, to what extent are you certain of that, look, we want to rationalize that at this moment we are just at that stage of going, let's say, to that level because cancer cells generally end up killing precisely because of the metastasis and the metastasis process is similar for all of us we can define what metastasis is metastasis is the ability of cells to be when they are housed in a tumor to get out of the tumor to reach other places in the body to invade and generate the tumors you have to go as effectively infecting tissue and what is the problem when they infect vital tissues for example the brain, lungs, liver, etc. and that is what causes most people to die of cancer effectively because you remove a tumor but it is not encapsulated you do not remove all the tissue infected by the cancer and then what you do is remove the tumor and in those infected tissues put this formula that you have discovered based on turmeric and that causes it to block there and it is even easier It is not in all tumors, it is you remove the primary tumor and apply its formulation only there to prevent that from that origin of that root it is believed that they take over and generally up to 100 other places now all cancers behave in this way with a tumor that generates metastasis and that therefore generates the reappearance of the cancer or that the cancer is not definitively defeated of course, effectively is to use the nomenclature of the malignant benign is that it does not generate metastasis and malignant is that it has the capacity to generate metastasis and has a dislike of fatality this if it started to work you I am going to ask why a series is required now of stage you are in search of financing of support to extend this and hopefully apply it to more cancers and also test it in humans you tell me that having the certainty in any case that it would work for you but basically to get to that you have also had to do a series of tests and be able to discover that indeed in different cancers this applies if we well it has been shown that in cells curcumin and our formulation that is useful, let's say, for various types of cancers and in cells, and then for us, precisely, we rationally want to move forward with the others, we're not sure, but if our scientific hypothesis would support, let's say, the projection of our experiments and one might think that if this were In fact, it is possible to discover with certainty that this works for a large number of tumors and to stop metastasis in the majority of cancers, then one could think of a cancer that does not necessarily have to be referred to radiotherapy in a chemotherapy that is of the The way in which the body begins to be bombarded to prevent metastasis from continuing or to eliminate the tissues that are still infected, we want to effectively eliminate all these types of treatments that are very aggressive and, on the other hand, our formulation is super innocuous, it is super healthy, unlike of almost all the other toxic milestones that you see that people have gastric problems that their hair falls out, many people die as a result of all the side effects in the case of our formulation both the active molecule that is curcumin and the other components that they have Those who are doctors are extremely healthy.
This is wonderful that one also thinks about the quality of life of patients who have cancer, where generally the greatest disorders are caused by these super-aggressive treatments. In the case of chemotherapy, people are really very bad in In terms of mood, the depressed physique, if you could not have that type of treatment, have one that is not invasive and it seems to me that it would be a radical change in the quality of life of patients, also with the idea of not effectively signing again. the cure now this means and this is also interesting because the chemo sees that a series of sessions is done there is no chemotherapy that manages to eradicate all the metastasis or kill let's say all the tissues that are bad there is not a single radiotherapy one enters as in a treatment scheme in this case is one application a single dose 112 one only is to wash the tissue as it does to you with this liquid and there already the goal of leaving the liquid and ultimately if it is the liquid it remains as doing action exactly if If, since it is healthy and has no defects, we show that it does not generate any bad effects on healthy cells, which it did preferentially on diseased cells, then it is super specific where it operates, that is, it is not a risk that they would do it to you if your illness was so serious.
We predict that this formulation can be applied to any tumor that it removes for anyone, anyone, how much is left now for that to be a more plausible reality? You tell me that we are in the phases where this has had an effect in animals and with that sample you can then project that this is going to work in human beings that we need to verify that it will work I don't know how laboratory tests are done in this sense and what we need so that this could be available to people I don't know if it would be an expensive treatment also because it sounds so simple to me I think that the people who see us probably also tell me that by extracting a plant from a part that the body can receive we have an antidote that could be so effective for cancer sounds magical I am going to explain to you, look at the part in any result that I have told you that sounds so nice.
There has been a collaboration of approximately 15 scientists. In fact, for example, I work in very close collaboration with Dr. Andrew Quest from the Faculty of Medicine. marx is collaborating with us doctor marcelo kogan the next one a warrior in addition to ten other researchers what we wanted was to have scientific certainty in our current result and in our current result to have the molecule convey the probable in cells animal models and perfect results we had a perfect result now we have to go through with the doctors we need the collaboration of doctors and experienced clinicians to be able to apply this in the indicated patients and that contemplates a magnitude of resources that is very different from what we are handling thank god We all have projects and we are also hosted by a very large one, but the resources are totally different, they are totally totally up to whoever articulates this because basically we are saying here that help is required, but when a group of scientists in our country investigates and has a certainty, let's say in animals of this caliber who is concerned that this is transferred to a technological development that could reach humans and that could generate such an important change in the development of cancer, the usual thing is that the second leg, let's say, of the experiments contemplate privately and for why because they are the ones who are capable of demonstrating and generating a medicine I am talking about a formulation that is a liquid but with batch-by-batch reproduction, there may be worldwide distribution, for example, all of this depends on a laboratory and what we What we did was first to protect our research, we made one for inside the mine in the US so that we can now attract, let's say, the private world but also the public world because it is precisely possible to pool the monetary contributions in order to have, let's say, a kind of little pig and redistribute it there because imagine working with patients is extremely expensive and extremely slow so someone who is really willing to take that leap and say look you know that this research makes scientific sense it has a clinical projection let's wait for the results and the results are not from one day to the next besides that How can you finally validate research in humans?
I am completely unaware of this, this has to be developed and tested in how many human beings and in how long and with what success rate for this research to be validated and there is a laboratory that wants to develop this to tempt him, perhaps distribute it in the world and do it as a validated therapy from the scientific world, how long does it take for that to happen but that question is a little more difficult because it will depend on each type of cancer each type of cancer has a specific projection and it will also depend on what stage each patient is in, of patients who are already more seriously ill and who supposedly may have a shorter life projection, we can perhaps create a more short-lived result, but in some patients who they are starting with cancer maybe you have to wait for the result for 10years but we are treating cancer let's see imagine that we have and we are look imagine that we are only talking to 10% what we are having management 10 percent of the patients that have been tested that is already trained if out of 10 people we have saved 100 We have saved 10 people's lives and now what happens we are very excited because our formulation was efficient in all the animals and that was going to ask in the animals it didn't matter if the cancer was more or less developed and it is that it was a more or less aggressive cancer, basically this formula worked for everything. solar line of melanoma more and we tried to face the best and our opponent was the toughest because because the cell line to begin with is very, it generates a lot of resistance to pharmacotherapy on the one hand and it also has a very great capacity to generate metastasis and for that reason It is that we are so excited because if in this line we were able to have that result we rationally hope that in the others we can also have similar results since he feels that he is looking at us for the best, I do not know privately who are the ones who contribute to this type of research We are necessarily talking about a laboratory.
You tell me here we need doctors, what is the role of doctors in order to validate this invention? Well, it is joint research that requires specialists and also requires contributions. In the case of contributions, it can effectively The usual thing is that when a drug has a lot of potential, the big pharma companies approach it now and the big pharma companies should not be afraid of them because, after all, they are the ones that generate the drugs that you buy in the pharmacy and you need certainty scientific for it when you have a family member who has cancer you don't want that it doesn't seem like this means that you really want to be certain because this also contemplates an economic investment and then on the one hand we don't have to demonize them we have to in fact us we want to do we want them to be our accomplices in this and our partners and on the other hand it also requires a lot of technical information technical information and that can be provided by clinicians to date we have involved pharmaceutical chemists biologists biochemists veterinarians etc. but we still need the clinical leap and The specialists are not in the field of surgery but also in the epidemiological field, which is to say that what you are asking me is clinical certainty, that is to say, how long do we need specialists in this field and to tell us if this is this is the dose and we are going to apply it in such a way now that what you tell me sounds like it still requires a more or less long time one could venture when this could be clinically proven because as well as taking all this is the reduction of the clinically proven concept when they tell you Look, this medication is accurate and it works and it is validated.
Look, I am going to put you in a context so that you understand my answer. The phase studies, which are the studies that are normally carried out to evaluate a medication, can contemplate 10, 15 or 20 years in this case. We have two caveats, one that the medicine that we generate, we are certain from the beginning, both from the active principle and from the other components, that it is safe, therefore we can walk much faster, and on the other hand, we are also talking about patients who have cancer. where the projection is indeed very adverse then that means that you can reduce all these gaps in lowering the thresholds for you and lowering the thresholds we could think in a term similar to five years four years God willing since we are lucky let's say that we actually approve all these these safeguards that we have not only do you have this is a we are certain that this is a medicine we are going to tell you a safe formula that means you do not see adverse effects of any kind or there are adverse effects but that in reality Regarding the benefit, they are very low, such as how it behaves, does this medication have some share of negativity or the truth is that it is super innocuous?
We see it not as the term is not innocuous because it has an effect, but I mean in terms of generating adverse consequences that people or now the animals in the future of the people we have not seen any adversity at all, neither in the cells nor in the animal model, that is, this is very well aspected and, on the contrary, you know that our medicine, but there is a rationale for this, also helps to the wound heals that the surgery heals, on the contrary, we have seen no version, you say that it helps effective healing, we also see, in addition to all the benefits that it would have for metastasis, the same university, others, it is designed in such a way that all the components are very safe it is possible good thing is that skipping everything that comes is possible to venture if this is a cheap expensive technology when one thinks that this could somehow replace chemotherapy because less one knows that cancer treatments are super expensive many families are left in ruins literally fighting cancer this could also perhaps be something that alleviates that costly burden cancer or projecting prices and costs is still very difficult the cost of the developments contemplate contemplate first in the preparation of the medicine plus the validation of this in the case of the elaboration that is our part it is extremely cheap it is very very very very cheap already but what will you have that what would be expensive that would be the validation with the patients that is what mainly expensive and that is precisely what the laboratories want is to somehow recover the investment that they already have for a week and we can have if we can get closer we can make more progress with that yes, on our part we are already advancing and testing, for example, with other models animals that other types of cancer can be very, very well cared for by our, as I know they are doing that, they are trying to make progress for other types of cancers, yes, but we also have resources for that because the resources we have are allocated to very specific projects now and we can't come and take money from a family's pocket to spend it again I don't correspond now but if we have all the disposition our commitment is to advance as much as possible and make the maximum sacrifice to effectively see what is what they are all What is the full potential of this that it can be effectively all metastatic tumors?
Well, I think it is fantastic news. I hope that he wants to have all the resources and there are private companies that can contribute if the state itself can make a greater effort if there are other countries. Maybe in the world that they can look at this development that you are doing in a very multidisciplinary team, everything and that they can support it would be wonderful, so I hope that this interview also serves that purpose so that wills come together and we can continue advancing and hopefully this become a reality for many patients facing
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