Andrew Huberman Talks About Testosterone OptimizationNov 13, 2021
Jurgen's experience, the hormone surge thing is always a bit of a complicated discussion, but there's a lot going on there right now that's really interesting, like what, well, for example, um, back to the topic of the supplements, I always say, look, their behaviors are the fundamental layer you have to do the right things for anything to sleep to learn for athletic performance, but then there are nutritional supplements, prescription drugs, and then off-label stuff like that which we always think of when you hear hormones in sports you always think raw. conversation about anabolics all things band we can talk about those things and how they work Years ago I used to work on androgens
testosteroneand its derivatives and how it affects brain development and body function fear and also mental states but there is a category of supplements that are very interesting that for most people who are not exploring the increase in
testosteronefor sports they work very well to increase testosterone by about 100 to 200 points you don't know 300 you don't know triple or anything like that and the main ones are two substances one It's called tongat ali oh yeah that's real huh yeah oh yeah because what's going on is the testosterone molecule.
Basically, it's transported in a cargo, so it can be in its free form, unbound, free testosterone and everyone says: oh , I want more free testosterone, you want more, but these are called sex hormone-binding globulins, so there is something called hormone-binding globulin. Sex hormones and albumin transport the testosterone molecule to the different tissues in the body, so you don't want all of your testosterone to be free, you want some of it bound so it can be delivered to the different tissues, including your brain, but if you have too much sex hormone binding globulin testosterone can't really do its thing right so tonga ali about 400 milligrams per day has the effect of increasing free testosterone and overall testosterone by about 100 to 200 points, so we're not talking about full trt or blasting or now i always have fun on youtube now they call it sports trt that's when you go over 200 milligrams a week sports this is basically you know you i have TRT which is normally about 200 milligrams and we say 200 milligrams when you look at a syringe, what is that?
That's a thousand milligrams, so the typical dose for testosterone replacement therapy is 200 milligrams given once a week. to two weeks, but when you look at a full syringe, what is that? So for a cc, a mill, that's 200 milligrams, typically for scipionate, which is sold a cc, a full cc is just a cc. Depends if you have threads that are a little narrow, okay, okay, but if you have a syringe that goes up to 10. What is that? That's 10 cc's That's that's 10 cc's Yeah, that's a thousand milligrams, that makes sense, so that would be two in that. and that's 200 milligrams tha ok ok as long as we go down like two syringes full yeah i mean actually i think a lot of people who think they need trt when i hear about men in their 20s and 30s look i'm on I am in my mid 40's and I can tell you that you can get and maintain very healthy testosterone levels without TRT if you do the right things, the behaviors, the nutrition, all the other things from the beginning, sometimes there are people who have hypocrine syndromes and things like that, there are a lot. of problems with guys who have head injuries and head injuries and absolutely and it would be an interesting conversation to talk about the role of testosterone in neural repair it's very interesting but when you look at trt I mean the the way that clinics and the doctors usually do to give 200 milligrams and then send people for two weeks and then come back because they can charge them to come back repeatedly. fifteen milligrams of testosterone a day so taking this massive dose and then waiting two weeks is absolutely foolish it's not like that it amazes me the medical profession would do this because it doesn't match any of the normal endocrinology patterns it just isn't how the body works the way it has been described to me to do it is to do it with an insulin syringe and do a small amount every three days that's correct yes so 0.2 milliliters you know 0.2 thousand, so maybe you know 20 to 60 milligrams every few days every other day or so that matches the normal pattern of release a lot more and avoids these estrogen crashes and a lot of the issues that overlap with estrogen are actually issues with estrogen prolactin which is a molecule that is involved in milk disappointment and lactating women but it actually turns off sexual desire and aggression you know this is interesting about prolactin so this happens in av It is brooding and it happens in humans.
As they've done this, a study published in the journal Nature, which is our kind of flagship journal, showed that when the husbands of pregnant women because of something, maybe a pheromone, maybe some scent from the pregnant woman, actually man's prolactin rises when pregnant puts body weight on guy starts accumulating body fat presumably to prepare father for long sleepless nights ahead because humans have always been co-parents wow im mostly co-parent we all know that women do a lot more but it's the teachers who are out there getting fat don't feel bad yeah that's what's happening with the father it's partly due to an increase in prolactin and testosterone and prolactin they work in the opposite way, so it's a very interesting thing, but the way you describe it is correct now. for people who are not prescribed trt but want to increase testosterone there are these plant compounds like tonga ali and another one that is very interesting is a nigerian shrub called phadoggia aggr essis and it mimics luteinizing hormone which is the hormone that it comes out of the hypothalamus which stimulates your testicles if you have them and your ovaries if you have them to make more testosterone or estrogen and those two herbal supplements together can give you a major boost in free and active testosterone so you said tongue god ali he can give you 100 to 200, yeah, about that, what does the other give you? fadoja is usually taken around 600 milligrams and that can mean the most dramatic effect I've ever seen. was someone you had low testosterone in the two lows or I think it was like two lows and bumped it up to the 700 range but that's about it but that's an outlier most people will see about a three hundred point to four hundred increase and that's what the two synergistically the dojo will really make the testicles grow that's a noticeable difference so everyone wants that well the reason I know about these things people are probably thinking like You know, the Huberman team got out of the back of their cars and that's not what it's about, it's that I do a certain amount of work with the military and I do a certain amount of work with professional athletes who can't put out compounds. of androgens from a syringe because they will lose their job or they have been doing that and they want to get out, although I am not going to get out of the organization, but there is a major professional sports organization where let's say if someone gets injured, I have to permission to take up to 200 milligrams a week of testosterone football no no no but well I guess you almost got me because I almost countered with the actual fact that it's hockey uh no though those guys have head injuries so say that again true head injury is a serious problem, obviously, so testosterone has the effects we are all aware of, like deepening of the voice, regrowth of facial hair muscle growth, etc., mainly because testosterone increases protein.
Long story short you look at a young man going through puberty he's a protein synthesizing machine yeah they eat the aed and they just grow and grow and grow and they're building muscle and they're lean and you know most of the time they're thin. but in any case, testosterone has some very interesting effects on the brain. The main mental effect of testosterone is that it makes exertion feel good, oh that makes sense and the reason it does that is the amygdala, this fear center in the brain, this anxiety center in the brain you have androgen receptors, you have testosterone receptors, and so the way this works in animals and in humans as well is that for most species, the males of that species never get a chance to mate properly, so which if you think about it, I'll probably pick an example where you'll know the exception because I know you know a lot about natural animals and animals that are hunted, but if you think about antlered animals like rams, there's been a lot of research, believe it or not, on the rams.
It would be fun I love to work you know rams have huge eggs and they have to fight for the right to mate yeah and fighting is a right choice and the decision to walk away is a choice usually they usually don't kill each other each other, although I know some. from injuries can cause death so these testosterone surges that occur seasonally in certain species like rams or even these little hamsters the males will rip each other's testicles off to fight for the right to mate , so that the males of a certain species have really overcome the fear of pain and punishment and the increase in testosterone is what causes the change to the willingness to engage in battle and therefore when humans take doses low or reasonable doses of testosterone or increase your testosterone or are Going through the strain of puberty and leaning into pain and challenge actually has the effect of making the body feel calm and good.
It's an urge just like sex is an urge or drinking water when you're thirsty. and like a drive this is all anchored deep in the hypothalamus this is not a cognitive thing that makes sense why young men in particular are really driven to do intense exercise and sports that are very very difficult that require extreme effort, it makes sense, yes and why when people are low testosterone they feel depressed and when people have increased testosterone they feel relief and anxiety as long as it is in the appropriate range. easily switch between video and audio experience on spotify you can listen to the jre in the background while using other apps and you can download episodes to save on data costs all free spotify is absolutely free you don't have to have a premium account to watch new episodes of jre you just need to search for the jre on your spotify app go to spotify now to get this full episode of the joe rogan experience
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